Human monocyte/macrophages activate by exposure to LPS overexpress NGF and NGF receptors. (Articolo in rivista)

Type

• Articolo in rivista (Classe)
• Prodotto della ricerca (Classe)

Label

• Human monocyte/macrophages activate by exposure to LPS overexpress NGF and NGF receptors. (Articolo in rivista) (literal)

Anno

• 2001-01-01T00:00:00+01:00 (literal)

Http://www.cnr.it/ontology/cnr/pubblicazioni.owl#doi

• 10.1016/S0165-5728(00)00441-0 (literal)

Alternative label

• Caroleo M.C. (1), Costa N. (2), Bracci-Laudiero L. (3), Aloe L (3). (2001)
  Human monocyte/macrophages activate by exposure to LPS overexpress NGF and NGF receptors.
  in Journal of neuroimmunology (Print); Elsevier, New York (Stati Uniti d'America)
  (literal)

Http://www.cnr.it/ontology/cnr/pubblicazioni.owl#autori

• Caroleo M.C. (1), Costa N. (2), Bracci-Laudiero L. (3), Aloe L (3). (literal)

Pagina inizio

• 193 (literal)

Pagina fine

• 201 (literal)

Http://www.cnr.it/ontology/cnr/pubblicazioni.owl#numeroVolume

• 113 (literal)

Rivista

• Journal of neuroimmunology (Rivista)

Http://www.cnr.it/ontology/cnr/pubblicazioni.owl#pagineTotali

• 9 (literal)

Http://www.cnr.it/ontology/cnr/pubblicazioni.owl#numeroFascicolo

• 2 (literal)

Note

• ISI Web of Science (WOS) (literal)

Http://www.cnr.it/ontology/cnr/pubblicazioni.owl#affiliazioni

• (1)Faculty of Pharmacy, Department of Pharmacobiology, University of Calabria, Cosenza, Italy. (2) Faculty of Pharmacy, University of Magna Grecia, Catanzaro, Italy (3) Institute of Neurobiology, CNR, Rome Italy (literal)

Titolo

• Human monocyte/macrophages activate by exposure to LPS overexpress NGF and NGF receptors. (literal)

Abstract

• Monocyte/macrophages (M/M) represent the main cellular component of the immune system involved in the inflammatory response. In the present study we investigate whether NGF is produced by M/M and is involved in this event. The results show that unstimulated human M/M produce NGF and its synthesis is stimulated by LPS. The increase of NGF is associated with enhanced expression of high affinity NGF receptor on M/M and with no changes of low affinity NGF receptors (p75). The neutralization of endogenous NGF by NGF antibody in LPS-activated M/M, leads to overexpression of p75 receptor causing apoptosis. These findings provide new insight in the mechanisms governing monocyte survival in the inflamed tissue, representing a crucial aspect of host defence and maintenance of homeostasis. (literal)

Editore

• Elsevier (Editore)

Prodotto di

• Istituto di neurobiologia e medicina molecolare (INMM) (Istituto)

Autore CNR

• LUIGI ALOE (Unità di personale interno)
• LUISA BRACCI LAUDIERO (Unità di personale interno)

Insieme di parole chiave

• Parole chiave di "Human monocyte/macrophages activate by exposure to LPS overexpress NGF and NGF receptors." (Insieme di parole chiave)

Incoming links:

Autore CNR di

• LUISA BRACCI LAUDIERO (Unità di personale interno)
• LUIGI ALOE (Unità di personale interno)

Prodotto

• Istituto di neurobiologia e medicina molecolare (INMM) (Istituto)

Http://www.cnr.it/ontology/cnr/pubblicazioni.owl#rivistaDi

• Journal of neuroimmunology (Rivista)

Editore di

• Elsevier (Editore)

Insieme di parole chiave di

• Parole chiave di "Human monocyte/macrophages activate by exposure to LPS overexpress NGF and NGF receptors." (Insieme di parole chiave)