Human monocyte/macrophages activate by exposure to LPS overexpress NGF and NGF receptors. (Articolo in rivista)

Type
Label
  • Human monocyte/macrophages activate by exposure to LPS overexpress NGF and NGF receptors. (Articolo in rivista) (literal)
Anno
  • 2001-01-01T00:00:00+01:00 (literal)
Http://www.cnr.it/ontology/cnr/pubblicazioni.owl#doi
  • 10.1016/S0165-5728(00)00441-0 (literal)
Alternative label
  • Caroleo M.C. (1), Costa N. (2), Bracci-Laudiero L. (3), Aloe L (3). (2001)
    Human monocyte/macrophages activate by exposure to LPS overexpress NGF and NGF receptors.
    in Journal of neuroimmunology (Print); Elsevier, New York (Stati Uniti d'America)
    (literal)
Http://www.cnr.it/ontology/cnr/pubblicazioni.owl#autori
  • Caroleo M.C. (1), Costa N. (2), Bracci-Laudiero L. (3), Aloe L (3). (literal)
Pagina inizio
  • 193 (literal)
Pagina fine
  • 201 (literal)
Http://www.cnr.it/ontology/cnr/pubblicazioni.owl#numeroVolume
  • 113 (literal)
Rivista
Http://www.cnr.it/ontology/cnr/pubblicazioni.owl#pagineTotali
  • 9 (literal)
Http://www.cnr.it/ontology/cnr/pubblicazioni.owl#numeroFascicolo
  • 2 (literal)
Note
  • ISI Web of Science (WOS) (literal)
Http://www.cnr.it/ontology/cnr/pubblicazioni.owl#affiliazioni
  • (1)Faculty of Pharmacy, Department of Pharmacobiology, University of Calabria, Cosenza, Italy. (2) Faculty of Pharmacy, University of Magna Grecia, Catanzaro, Italy (3) Institute of Neurobiology, CNR, Rome Italy (literal)
Titolo
  • Human monocyte/macrophages activate by exposure to LPS overexpress NGF and NGF receptors. (literal)
Abstract
  • Monocyte/macrophages (M/M) represent the main cellular component of the immune system involved in the inflammatory response. In the present study we investigate whether NGF is produced by M/M and is involved in this event. The results show that unstimulated human M/M produce NGF and its synthesis is stimulated by LPS. The increase of NGF is associated with enhanced expression of high affinity NGF receptor on M/M and with no changes of low affinity NGF receptors (p75). The neutralization of endogenous NGF by NGF antibody in LPS-activated M/M, leads to overexpression of p75 receptor causing apoptosis. These findings provide new insight in the mechanisms governing monocyte survival in the inflamed tissue, representing a crucial aspect of host defence and maintenance of homeostasis. (literal)
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