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Toxicity of unwanted intermediates and products formed during accidental thermal decomposition of chemicals (Articolo in rivista)
- Type
- Label
- Toxicity of unwanted intermediates and products formed during accidental thermal decomposition of chemicals (Articolo in rivista) (literal)
- Anno
- 2008-01-01T00:00:00+01:00 (literal)
- Alternative label
- Http://www.cnr.it/ontology/cnr/pubblicazioni.owl#autori
- ANDREOZZI R.; DI SOMMA I.; POLLIO A.; PINTO G.; SANCHIRICO R (literal)
- Pagina inizio
- Pagina fine
- Http://www.cnr.it/ontology/cnr/pubblicazioni.owl#numeroVolume
- Rivista
- Note
- ISI Web of Science (WOS) (literal)
- Http://www.cnr.it/ontology/cnr/pubblicazioni.owl#affiliazioni
- Università di Napoli, CNR-IRC (literal)
- Titolo
- Toxicity of unwanted intermediates and products formed during accidental thermal decomposition of chemicals (literal)
- Abstract
- The problem of the formation of unwanted substances that can occur during thermal decomposition of chemicals is studied from a toxicological
point of view.
Two species, ethyl parathion (a widely used pesticide) and cumene hydroperoxide (an intermediate for the industrial production of phenol and
acetone), are selected for this investigation. The hazards associated to their accidental thermal decomposition are estimated on the basis of the
(known) intermediates and products formed by means of a computational tool (ECOSAR programme) and assessed experimentally by means of
algal bioassays. Green alga Pseudokirchneriella is used as target organism for all the toxicological assessments. The results of these tests on the
samples collected during the thermal decomposition of the two studied species indicate that in the case of ethyl parathion the decomposition process
gives rise to a mixture of compounds which are more toxic than the parent species. On the other hand, the decomposition of cumene hydroperoxide
in cumene results into the formation of different species whose toxicity towards the adopted organism is lower than that shown by the starting
compound. A procedure is proposed to ascertain when it is necessary or it is avoidable to carry out further investigations that involve the analytical
resolution of mixtures resulting from the thermal decomposition process.
This approach is suggested as a preliminary screening to identify the hazards associated with an accidental decomposition either of pure chemicals
or of mixtures of compounds.
© 2007 Elsevier B.V. All rights reserved. (literal)
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