http://www.cnr.it/ontology/cnr/individuo/prodotto/ID4264

Immune response at birth, long-term immune memory and 2 years follow-up after in-utero anti-HBV DNA immunization (Articolo in rivista)

Type

Articolo in rivista (Classe)
Prodotto della ricerca (Classe)

Label

Immune response at birth, long-term immune memory and 2 years follow-up after in-utero anti-HBV DNA immunization (Articolo in rivista) (literal)

Anno

2004-01-01T00:00:00+01:00 (literal)

Http://www.cnr.it/ontology/cnr/pubblicazioni.owl#doi

10.1038/sj.gt.3302179 (literal)

Alternative label

Fazio V.M.*; Ria F."; Franco E.^; Rosati P.**; Cannelli G.""; Signori E.*°; Parrella P.'; Zaratti L.^; Iannace E.""; Monego G.**; Blogna S.^^; Fioretti D.°'; Iurescia S.°'; Filippetti R.^^; Rinaldi M.° (2004)
Immune response at birth, long-term immune memory and 2 years follow-up after in-utero anti-HBV DNA immunization
in Gene therapy (Basingstoke)
(literal)

Http://www.cnr.it/ontology/cnr/pubblicazioni.owl#autori

Fazio V.M.*; Ria F.\"; Franco E.^; Rosati P.**; Cannelli G.\"\"; Signori E.*°; Parrella P.'; Zaratti L.^; Iannace E.\"\"; Monego G.**; Blogna S.^^; Fioretti D.°'; Iurescia S.°'; Filippetti R.^^; Rinaldi M.° (literal)

Pagina inizio

544 (literal)

Pagina fine

551 (literal)

Http://www.cnr.it/ontology/cnr/pubblicazioni.owl#altreInformazioni

2010 Impact Factor: 4.538 KeyWords Plus: B SURFACE-ANTIGEN; HEPATITIS-B; PLASMID DNA; GENE-TRANSFER; INTRAMUSCULAR INJECTION; NEONATAL TOLERANCE; FETAL IMMUNIZATION; VIRUS-INFECTION; MALARIA VACCINE; PORCINE MUSCLE Publisher: NATURE PUBLISHING GROUP, MACMILLAN BUILDING, 4 CRINAN ST, LONDON N1 9XW, ENGLAND Web of Science Category: Biochemistry & Molecular Biology; Biotechnology & Applied Microbiology; Genetics & Heredity; Medicine, Research & Experimental Subject Category: Biochemistry & Molecular Biology; Biotechnology & Applied Microbiology; Genetics & Heredity; Research & Experimental Medicine IDS Number: 780PU ISSN: 0969-7128 (literal)

Http://www.cnr.it/ontology/cnr/pubblicazioni.owl#numeroVolume

11 (literal)

Rivista

Gene therapy (Rivista)

Http://www.cnr.it/ontology/cnr/pubblicazioni.owl#pagineTotali

8 (literal)

Http://www.cnr.it/ontology/cnr/pubblicazioni.owl#numeroFascicolo

6 (literal)

Note

ISI Web of Science (WOS) (literal)

Http://www.cnr.it/ontology/cnr/pubblicazioni.owl#affiliazioni

* Interdisciplinary Center for Biomedical Research, Laboratory for Molecular Medicine and BioTechnology, Università 'Campus Bio-Medico', Rome and Laboratory for Gene Therapy and Oncology, IRCCS H 'Casa Sollievo della Sofferenza', San Giovanni Rotondo (FG), Italy; \" Institutes of Patologia Generale, Università Cattolica del Sacro Cuore (UCSC), Rome, Italy; ^ Department of Sanità Pubblica e Biologia Cellulare, Università 'Tor Vergata', Rome, Italy; ** Ostetricia e Ginecologia, Università Cattolica del Sacro Cuore (UCSC), Rome, Italy; \"\" Anestesiologia e Rianimazione, Università Cattolica del Sacro Cuore (UCSC), Rome, Italy; ° Istituto Neurobiologia e Medicina Molecolare, Sezione Medicina Molecolare, Divisione Gene-Medicine, CNR, Rome, Italy; ' Laboratory for Gene Therapy and Oncology, IRCCS H. 'Casa Sollievo della Sofferenza', San Giovanni Rotondo (FG), Italy; ^^ Servizio Stabulario, Università Cattolica del Sacro Cuore (UCSC), Rome, Italy. (literal)

Titolo

Immune response at birth, long-term immune memory and 2 years follow-up after in-utero anti-HBV DNA immunization (literal)

Abstract

Infections occurring at the end of pregnancy, during birth or by breastfeeding are responsible for the high toll of death among first-week infants. In-utero DNA immunization has demonstrated the effectiveness in inducing specific immunity in newborns. A major contribution to infant immunization would be achieved if a vaccine proved able to be protective as early as at the birth, preventing the typical 'first-week infections'. To establish its potential for use in humans, in-utero DNA vaccination efficiency has to be evaluated for short- and long-term safety, protection at delivery, efficacy of boosts in adults and effective window/s for modulation of immune response during pregnancy, in an animal model suitable with human development. Here we show that a single intramuscular in-utero anti-HBV DNA immunization at two-thirds of pig gestation produces, at birth, antibody titers considered protective in humans. The boost of antibody titers in every animal following recall at 4 and 10 months demonstrates the establishment of immune memory. The safety of in-utero fetus manipulation is guaranteed by short-term (no fetus loss, lack of local alterations, at-term spontaneous delivery, breastfeeding) and long-term (2 years) monitoring. Treatment of fetuses closer to delivery results in immune ignorance without induction of tolerance. This result highlights the repercussion of selecting the appropriate time point when this approach is used to deliver therapeutic genes. All these findings illustrate the relevance of naked DNA-based vaccination technology in therapeutic efforts aimed to prevent the high toll of death among first-week infants. (literal)

Prodotto di

Autore CNR

SANDRA IURESCIA (Persona)
MONICA RINALDI (Unità di personale interno)
DANIELA FIORETTI (Unità di personale interno)
EMANUELA SIGNORI (Unità di personale interno)

Insieme di parole chiave

Keywords of "Immune response at birth, long-term immune memory and 2 years follow-up after in-utero anti-HBV DNA immunization" (Insieme di parole chiave)

Incoming links:

Autore CNR di

EMANUELA SIGNORI (Unità di personale interno)
MONICA RINALDI (Unità di personale interno)
DANIELA FIORETTI (Unità di personale interno)
SANDRA IURESCIA (Persona)

Prodotto

Http://www.cnr.it/ontology/cnr/pubblicazioni.owl#rivistaDi

Gene therapy (Rivista)

Insieme di parole chiave di

Keywords of "Immune response at birth, long-term immune memory and 2 years follow-up after in-utero anti-HBV DNA immunization" (Insieme di parole chiave)

data.CNR.it