Toxicology investigations with cell culture systems: 20 years after. (Articolo in rivista)

Type
Label
  • Toxicology investigations with cell culture systems: 20 years after. (Articolo in rivista) (literal)
Anno
  • 2004-01-01T00:00:00+01:00 (literal)
Alternative label
  • Zucco F., De Angelis I., Testai E., Stammati A. (2004)
    Toxicology investigations with cell culture systems: 20 years after.
    in Toxicology in vitro
    (literal)
Http://www.cnr.it/ontology/cnr/pubblicazioni.owl#autori
  • Zucco F., De Angelis I., Testai E., Stammati A. (literal)
Pagina inizio
  • 153 (literal)
Pagina fine
  • 163 (literal)
Http://www.cnr.it/ontology/cnr/pubblicazioni.owl#altreInformazioni
  • Impact Factor 1.464 (literal)
Http://www.cnr.it/ontology/cnr/pubblicazioni.owl#numeroVolume
  • 18 (literal)
Rivista
Note
  • ISI Web of Science (WOS) (literal)
Http://www.cnr.it/ontology/cnr/pubblicazioni.owl#affiliazioni
  • 1 = CNR, INMM, Rome, Italy; 2,3,4 = Istituto Superiore di Sanità, Lab. T.C.E., Rome, Italy (literal)
Titolo
  • Toxicology investigations with cell culture systems: 20 years after. (literal)
Abstract
  • From almost 20 years the \"in vitro\" model has gained a wide ground in toxicological investigation, providing advanced tools, reliable protocols, mechanistic information. These advancements have been done thanks to different approaches, addressed at improving chemical testing and validating procedures, at exploring the cellular and molecular basis of toxicity, at studying the modifications that xenobiotics undergo in the cellular environment. In this review the most advanced cellular models, the mechanisms of cell death, the techniques to monitor gene activation, following chemical exposure, is highlighted. Moreover the more recent in vitro models to approach the biotransformation issue will be presented. (literal)
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