Role of cholecystokinin-8 in nerve growth factor and nerve growth factor mrna expression in carrageenan-induced joint inflammation in adult rats. (Articolo in rivista)

Type

• Prodotto della ricerca (Classe)
• Articolo in rivista (Classe)

Label

• Role of cholecystokinin-8 in nerve growth factor and nerve growth factor mrna expression in carrageenan-induced joint inflammation in adult rats. (Articolo in rivista) (literal)

Anno

• 2002-01-01T00:00:00+01:00 (literal)

Alternative label

• Manni L., Lundeberg T., Tirassa P., Aloe L. (2002)
  Role of cholecystokinin-8 in nerve growth factor and nerve growth factor mrna expression in carrageenan-induced joint inflammation in adult rats.
  in Rheumatology (Oxf. Print)
  (literal)

Http://www.cnr.it/ontology/cnr/pubblicazioni.owl#autori

• Manni L., Lundeberg T., Tirassa P., Aloe L. (literal)

Pagina inizio

• 787 (literal)

Pagina fine

• 792 (literal)

Http://www.cnr.it/ontology/cnr/pubblicazioni.owl#numeroVolume

• 41 (literal)

Rivista

• Rheumatology (Rivista)

Http://www.cnr.it/ontology/cnr/pubblicazioni.owl#numeroFascicolo

• 7 (literal)

Note

• ISI Web of Science (WOS) (literal)

Http://www.cnr.it/ontology/cnr/pubblicazioni.owl#affiliazioni

• Institute of Neurobiology and Molecular Medicine, CNR, Viale Marx 15, 00137 Rome, Italy. (literal)

Titolo

• Role of cholecystokinin-8 in nerve growth factor and nerve growth factor mrna expression in carrageenan-induced joint inflammation in adult rats. (literal)

Abstract

• The aim of our study was to investigate the role of cholecystokinin-8 (CCK-8), which is able to induce the synthesis of nerve growth factor (NGF), in the joint inflammation of carrageenan-injected rats. METHODS: Adult rats were injected in the ankle joint with carrageenan, with or without CCK-8 or a CCK receptor antagonist (proglumide), and tissue swelling, NGF levels and NGF mRNA expression were assessed. RESULTS: Expression of NGF and NGF mRNA increased transiently after carrageenan injection. This effect was not altered by CCK-8 injection but was inhibited by the CCK receptor antagonist. The decrease in NGF level after treatment with the antagonist was concurrent with an increase in paw swelling. CONCLUSIONS: The results demonstrate that, whereas CCK-8 has no anti-inflammatory action in carrageenan-injected animals, proglumide induces a worsening of inflammation and reduces the expression of both NGF and NGF mRNA in inflamed ankle joints. Our data point to a regulatory action of CCK-8 on NGF synthesis during acute synovitis and suggest a role for NGF in the healing phase of inflammation. (literal)

Prodotto di

• Istituto di neurobiologia e medicina molecolare (INMM) (Istituto)

Autore CNR

• LUIGI ALOE (Unità di personale interno)
• LUIGI MANNI (Persona)
• PAOLA TIRASSA (Unità di personale interno)

Incoming links:

Prodotto

• Istituto di neurobiologia e medicina molecolare (INMM) (Istituto)

Autore CNR di

• LUIGI ALOE (Unità di personale interno)
• PAOLA TIRASSA (Unità di personale interno)
• LUIGI MANNI (Persona)

Http://www.cnr.it/ontology/cnr/pubblicazioni.owl#rivistaDi

• Rheumatology (Rivista)