http://www.cnr.it/ontology/cnr/individuo/prodotto/ID42288
Meeting Report: Risk Assessment of Tamiflu Use Under Pandemic Conditions (Articolo in rivista)
- Type
- Label
- Meeting Report: Risk Assessment of Tamiflu Use Under Pandemic Conditions (Articolo in rivista) (literal)
- Anno
- 2008-01-01T00:00:00+01:00 (literal)
- Http://www.cnr.it/ontology/cnr/pubblicazioni.owl#doi
- 10.1289/ehp.11310 (literal)
- Alternative label
- Http://www.cnr.it/ontology/cnr/pubblicazioni.owl#autori
- SINGER A.C (1); HOWARD B.M. (2); JOHNSON A.C. (3); KNOWLES C.J. (2); JACKMAN S. (2); ACCINELLI C. (4); BARRA CARACCIOLO A. (5); BERNARD I. (2); BIRD S. (6); BOUCARD T. (7); BOXALL A. (8); BRIAN J.V. (9); CARTMELL E. (10); CHUBB C. (11); CHURCHLEY J. (12); COSTIGAN S. (13); CRANE M. (14); DEMPSEY M.J. (15); DORRINGTON b. (16); ELLOR B. (17); FICK J. (18); HOLMES J. (19); HUTCHINSON T. (20); KARCHER F. (21); KELLEHER S.L. (15); MARSDEN P. (22); NOONE G. (23); NUNN M.A. (1); OXFORD J. (24); RACHWAL T. (25); ROBERTS N. (26); ROBERTS M. (27); SACCA' M.L. (4); SANDERS M. (28); STRAUB J.O. (26); TERRY A. (29); THOMAS D. (27); TOOVEY S. (26); TOWNSEND R. (30); VOULVOULIS N. (31); WATTS C. (14) (literal)
- Pagina inizio
- Pagina fine
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- Rivista
- Http://www.cnr.it/ontology/cnr/pubblicazioni.owl#note
- Http://www.cnr.it/ontology/cnr/pubblicazioni.owl#pagineTotali
- Note
- ISI Web of Science (WOS) (literal)
- Http://www.cnr.it/ontology/cnr/pubblicazioni.owl#affiliazioni
- 1) Centre for Ecology & Hydrology, Oxford, United Kingdom;
2) Environmental Knowledge Transfer Network, University of Oxford, Oxford, United Kingdom;
3) Centre for Ecology & Hydrology, Wallingford, Oxfordshire, United Kingdom;
4) University of Bologna, Bologna, Italy;
5) Italian National Research Council, Rome, Italy;
6) South West Water, Exeter, United Kingdom;
7) Environment Agency, Wallingford, United Kingdom;
8) University of York, York, United Kingdom;
9) Brunel University, London, United Kingdom;
10) Cran field University, Cran field, United Kingdom;
11) Environment Agency, Bristol, United Kingdom;
12) Severn Trent Water, Coventry, United Kingdom;
13) UK Government Department of Health, London, United Kingdom;
14) WCA Environment Ltd., Faringdon, United Kingdom;
15) Manchester Metropolitan University, Manchester, United Kingdom;
16) Northumbrian Water Group (Essex & Suffolk Water), Chelmsford, United Kingdom;
17) United Utilities, Warrington, United Kingdom;
18) Umeå University, Umeå, Sweden;
19) University of Oxford, Oxford, United Kingdom;
20) AstraZeneca, Brixham, Devon, United Kingdom;
21) Health Threats Unit, European Commission, Luxembourg;
22) Drinking Water Inspectorate, London, United Kingdom;
23) Worshipful Company of Water Conservators, London, United Kingdom;
24) Retroscreen Ltd./Barts and The London, Queen Mary 's School of Medicine and Dentistry, London, United Kingdom;
25) Independent Consultant, West Molesey, Surrey, United Kingdom;
26) F.Hoffmann-La Roche Ltd, Basel, Switzerland;
27) UK Government Department for Environment, Food and Rural Affairs, London, United Kingdom;
28) Centre for Environment, Fisheries and Aquaculture Science, Weymouth, United Kingdom;
29) Cambridge Environmental Assessments, Cambridge, United Kingdom;
30) Royal Society of Chemistry, London, United Kingdom;
31) Imperial College London, London, United Kingdom (literal)
- Titolo
- Meeting Report: Risk Assessment of Tamiflu Use Under Pandemic Conditions (literal)
- Abstract
- On 3 October 2007, 40 participants with diverse expertise attended the workshop Tamiflu and the
Environment: Implications of Use under Pandemic Conditions to assess the potential human health
impact and environmental hazards associated with use of Tamiflu during an influenza pandemic.
Based on the identification and risk-ranking of knowledge gaps, the consensus was that oseltamivir
ethylester-phosphate (OE-P) and oseltamivir carboxylate (OC) were unlikely to pose an ecotoxicologic
hazard to freshwater organisms. OC in river water might hasten the generation of OCresistance
in wildfowl, but this possibility seems less likely than the potential disruption that could
be posed by OC and other pharmaceuticals to the operation of sewage treatment plants. The workgroup
members agreed on the following research priorities: a) available data on the ecotoxicology of
OE-P and OC should be published; b) risk should be assessed for OC-contaminated river water generating
OC-resistant viruses in wildfowl; c) sewage treatment plant functioning due to microbialinhibition by neuraminidase inhibitors and other antimicrobials used during a pandemic should beinvestigated; and d) realistic worst-case exposure scenarios should be developed. Additional modelingwould be useful to identify localized areas within river catchments that might be prone to high
pharmaceutical concentrations in sewage treatment plant effluent. Ongoing seasonal use of Tamiflu
in Japan offers opportunities for researchers to assess how much OC enters and persists in the
aquatic environment. Key words: antiviral, drug, ecotoxicology, influenza, pandemic, pharmaceutical,
pollution, sewage treatment plant, Tamiflu. (literal)
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- Autore CNR
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