http://www.cnr.it/ontology/cnr/individuo/prodotto/ID42107
INVESTIGATING THE ESTROGENIC RISK ALONG THE RIVER PO AND ITS INTERMEDIATE SECTION (Articolo in rivista)
- Type
- Label
- INVESTIGATING THE ESTROGENIC RISK ALONG THE RIVER PO AND ITS INTERMEDIATE SECTION (Articolo in rivista) (literal)
- Anno
- 2006-01-01T00:00:00+01:00 (literal)
- Alternative label
VIGANÒ L., MANDICH A., BENFENATI E., BERTOLOTTI R., BOTTERO S., PORAZZI E., AGRADI E. (2006)
INVESTIGATING THE ESTROGENIC RISK ALONG THE RIVER PO AND ITS INTERMEDIATE SECTION
in Archives of environmental contamination and toxicology (Print)
(literal)
- Http://www.cnr.it/ontology/cnr/pubblicazioni.owl#autori
- VIGANÒ L., MANDICH A., BENFENATI E., BERTOLOTTI R., BOTTERO S., PORAZZI E., AGRADI E. (literal)
- Pagina inizio
- Pagina fine
- Http://www.cnr.it/ontology/cnr/pubblicazioni.owl#numeroVolume
- Rivista
- Note
- ISI Web of Science (WOS) (literal)
- Http://www.cnr.it/ontology/cnr/pubblicazioni.owl#affiliazioni
- Istituto di Ricerca sulle Acque, CNR, 20047 Brugherio (Milan), Italy
Dipartimento di Biologia Sperimentale, Ambientale ed Applicata, Università di Genova, Viale Benedetto XV 5, 16132, Genoa, Italy
Dipartimento Ambiente e Salute, Istituto di Ricerche Farmacologiche ''Mario Negri'' Via Eritrea 62, 20157 Milan, Italy
Istituto di Scienze Farmacologiche, Università di Milano, Via Balzaretti 9, 20133 Milan, Italy (literal)
- Titolo
- INVESTIGATING THE ESTROGENIC RISK ALONG THE RIVER PO AND ITS INTERMEDIATE SECTION (literal)
- Abstract
- Different endpoints have been used to investigate the
occurrence of estrogenic risk along the Po River, particularly its
middle section. An in vitro assay based on recombinant yeast
could not detect estrogenic activity in bed sediments of the
Italian river or in bile samples of five Cyprinid species, with the
only exception being one carp (Cyprinus carpio) captured
downstream of the River Lambro, a polluted tributary of the
middle River Po. Chemical analyses of fish bile and water
samples from the same middle section showed diffuse contamination
by moderately low levels of estrogenic chemicals
(estrone [E1], 17b-estradiol, estriol [E3], 17a-ethinylestradiol,
4-nonylphenol [NP], 4-tert-octylphenol [tOP], 4-n-octylphenol,
and bisphenol A) but they were of limited help in understanding
the risk present in the downstream area where intersex barbel
were previously found. In contrast, the analyses of River
Lambro waters showed that this tributary is a source to the
middle River Po of all eight estrogens investigated. Analyses of
bed sediments and macroinvertebrates from the same area
consistently showed at least two levels of contamination, with
the downstream stretch showing higher concentrations of
natural steroids (E1 and E3) and xenoestrogens (NP and tOP).
Accordingly, new histologic examinations undertaken on
young barbel (Barbus sp.) showed intersex gonads only in the
individuals captured in the downstream stretch, thereby confirming
previous results. Present findings confirm the occurrence
of disrupting conditions in the middle River Po and
provide the first suggestions of cause-effect relationships. (literal)
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- Autore CNR
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