http://www.cnr.it/ontology/cnr/individuo/prodotto/ID4209
Effect of exogenous administration of nerve growth factor in the retina of rats with inherited retinitis pigmentosa. (Articolo in rivista)
- Type
- Label
- Effect of exogenous administration of nerve growth factor in the retina of rats with inherited retinitis pigmentosa. (Articolo in rivista) (literal)
- Anno
- 2005-01-01T00:00:00+01:00 (literal)
- Alternative label
Lenzi L.1, Coassin M.2, Lambiase A.3, Bonini S.4, Amendola T.5, Aloe L.6 (2005)
Effect of exogenous administration of nerve growth factor in the retina of rats with inherited retinitis pigmentosa.
in Vision research (Oxf.)
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- Lenzi L.1, Coassin M.2, Lambiase A.3, Bonini S.4, Amendola T.5, Aloe L.6 (literal)
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- Impact Factor = 2.027 (literal)
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- 1,5,6 = Institute of Neurobiology and Molecular Medicine, Neurobiology Section, CNR, Viale Marx 43/15, 00137 Rome, Italy;
2,3,4 = CIR Laboratory of Ophthalmology, Campus Bio-Medico and Fondazione G.Bietti, Rome, Italy. (literal)
- Titolo
- Effect of exogenous administration of nerve growth factor in the retina of rats with inherited retinitis pigmentosa. (literal)
- Abstract
- NGF is implicated in retinal damage regression. To study whether this is a direct effect or an effect mediated by NGF on other endogenous biological mediators, we investigated the effect of exogenous administration of NGF in RCS rats affected by retinitis pigmentosa. We found that NGF administration exerts a rescue effect on photoreceptors in this animal model. NGF injection enhances brain-derived neurotrophic factor, â-fibroblast growth factor, transforming growth factor-â, vascular endothelial factor and neuropeptide-Y. This suggests that NGF has an effect on RCS rat retina, probably also through the stimulation of other biological mediators produced and released in the retina. (literal)
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