IN VIVO EXPOSURE OF CARP TO GRADED CONCENTRATIONS OF BISPHENOL A (Articolo in rivista)

Type
Label
  • IN VIVO EXPOSURE OF CARP TO GRADED CONCENTRATIONS OF BISPHENOL A (Articolo in rivista) (literal)
Anno
  • 2007-01-01T00:00:00+01:00 (literal)
Alternative label
  • MANDICH A., BENFENATI E., BOTTERO S., CEVASCO A., ERRATICO C., MAGGIONI S., MASSARI A., PEDEMONTE F., VIGANÒ L. (2007)
    IN VIVO EXPOSURE OF CARP TO GRADED CONCENTRATIONS OF BISPHENOL A
    in General and comparative endocrinology (Print)
    (literal)
Http://www.cnr.it/ontology/cnr/pubblicazioni.owl#autori
  • MANDICH A., BENFENATI E., BOTTERO S., CEVASCO A., ERRATICO C., MAGGIONI S., MASSARI A., PEDEMONTE F., VIGANÒ L. (literal)
Pagina inizio
  • 15 (literal)
Pagina fine
  • 24 (literal)
Http://www.cnr.it/ontology/cnr/pubblicazioni.owl#numeroVolume
  • 153 (literal)
Rivista
Note
  • ISI Web of Science (WOS) (literal)
Http://www.cnr.it/ontology/cnr/pubblicazioni.owl#affiliazioni
  • Department of Biology, University of Genoa, Italy Department of Environmental Health Sciences, Mario Negri Institute for Pharmacological Research (Milan), Italy Water Research Institute (IRSA - CNR), 20047 Brugherio (Milan), Italy (literal)
Titolo
  • IN VIVO EXPOSURE OF CARP TO GRADED CONCENTRATIONS OF BISPHENOL A (literal)
Abstract
  • A wide range of environmental pollutants commonly termed endocrine disrupters (ED) can mimic steroid hormones causing adverse health eVects. Recent studies showed that bisphenol A (BPA) together with other estrogenic chemicals, may be responsible for the disrupting eVects observed in Wsh of the middle River Po. The present study has investigated the potential role of BPA in inducing this kind of eVects and to this aim, 1-year-old (k1) common carp were exposed for 14 days to graded concentrations of BPA (1, 10, 100, and 1000 ?g/L). Histological alterations of gonads were described and compared to vitellogenin (VTG) and sex steroid levels. In carp males, BPA caused severe alterations of testis structure starting from 1 ?g/L. Several specimens lost the typical lobular structure showing spermatogenic cysts intermingled with free spermatozoa often degenerating into the lumen. Oocyte atresia was observed starting from 1 ?g BPA/L, concerning 57.1% of females at the highest concentration (1000 ?g BPA/L). A few carp from the same highest treatment also showed intersexuality (27%). Oestradiol-17? (E2) signiWcantly decreased both in 1 and 10 ?g BPA/L exposed carp reaching again values not signiWcantly diVerent from control in 1000 ?g BPA/L. At this concentration, a signiWcant reduction of testosterone (T) was observed in both males and females. The mean plasma concentration of VTG signiWcantly increased in 1000 ?g BPA/L exposed carp, even if a growing number of responsive carp was observed starting from the environmental concentrations (1 and 10 ?g BPA/L). © 2007 Elsevier Inc. All rights reserved. (literal)
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