Effect of chronic olanzapine treatment on nerve growth factor and brain-derived neurotrophic factor in the rat brain. (Articolo in rivista)

Type

• Articolo in rivista (Classe)
• Prodotto della ricerca (Classe)

Label

• Effect of chronic olanzapine treatment on nerve growth factor and brain-derived neurotrophic factor in the rat brain. (Articolo in rivista) (literal)

Anno

• 2005-01-01T00:00:00+01:00 (literal)

Alternative label

• Angelucci F.1, Aloe L.2, Iannitelli A.3, Gruber S.H.4, Mathe A.A.5 (2005)
  Effect of chronic olanzapine treatment on nerve growth factor and brain-derived neurotrophic factor in the rat brain.
  in European neuropsychopharmacology
  (literal)

Http://www.cnr.it/ontology/cnr/pubblicazioni.owl#autori

• Angelucci F.1, Aloe L.2, Iannitelli A.3, Gruber S.H.4, Mathe A.A.5 (literal)

Pagina inizio

• 311 (literal)

Pagina fine

• 317 (literal)

Http://www.cnr.it/ontology/cnr/pubblicazioni.owl#altreInformazioni

• Impact Factor = 3.510 (literal)

Http://www.cnr.it/ontology/cnr/pubblicazioni.owl#numeroVolume

• 15/3 (literal)

Rivista

• European neuropsychopharmacology (Rivista)

Note

• ISI Web of Science (WOS) (literal)

Http://www.cnr.it/ontology/cnr/pubblicazioni.owl#affiliazioni

• 1,4,5 = Karolinska Institutet, NEUROTEC Department, Karolinska University Hospital-Huddinge, Psychiatry, SE-14186 Stockholm, Sweden; 1,2 = Institute of Neurobiology and Molecular Medicine, National Research Council (CNR), Viale Marx 15, I-00137, Rome, Italy; 3 = 3rd Psychiatric Clinic, Department of Psychiatric Sciences and Psychological Medicine, University of Rome La Sapienza, Via di Torre Argentina, 21, 00186 Rome, Italy. (literal)

Titolo

• Effect of chronic olanzapine treatment on nerve growth factor and brain-derived neurotrophic factor in the rat brain. (literal)

Abstract

• Nerve growth factor (NGF) and brain-derived neurotrophic factor (BDNF) are proteins involved in neuronal survival, neurite outgrowth and synapse formation. Recent observations suggest that treatment with typical and atypical antipsychotic drugs affect NGF and BDNF levels in the rat brain. The atypical antipsychotic olanzapine has a low incidence of side effects, such as extrapyramidal and anticholinergic symptoms. Since NGF and BDNF are involved in the regulation of cholinergic, dopaminergic and serotonergic neurons in the central nervous system (CNS) we hypothesized that chronic olanzapine treatment will influence the distribution of NGF and BDNF in the rat brain. To test this hypothesis we administered olanzapine for 29 days in the drinking water at the doses of 3 and 15 mg/kg body weight and measured the levels of NGF and BDNF in the brain of Wistar rats. Olanzapine increased NGF in the hippocampus, occipital cortex and hypothalamus. In contrast, olanzapine decreased BDNF in the hippocampus and frontal cortex. Although the significance of these findings is not clear, a heuristic hypothesis is that olanzapine's clinical effects and a favorable side effect profile are in part mediated by neurotrophins. (literal)

Prodotto di

• Istituto di neurobiologia e medicina molecolare (INMM) (Istituto)
• Funzioni del S.N./Neurotrofine (SV.P16.007.001) (Modulo)

Autore CNR

• LUIGI ALOE (Unità di personale interno)

Insieme di parole chiave

• Keywords of "Effect of chronic olanzapine treatment on nerve growth factor and brain-derived neurotrophic factor in the rat brain." (Insieme di parole chiave)

Incoming links:

Prodotto

• Istituto di neurobiologia e medicina molecolare (INMM) (Istituto)
• Funzioni del S.N./Neurotrofine (SV.P16.007.001) (Modulo)

Autore CNR di

• LUIGI ALOE (Unità di personale interno)

Http://www.cnr.it/ontology/cnr/pubblicazioni.owl#rivistaDi

• European neuropsychopharmacology (Rivista)

Insieme di parole chiave di

• Keywords of "Effect of chronic olanzapine treatment on nerve growth factor and brain-derived neurotrophic factor in the rat brain." (Insieme di parole chiave)