Splicing of mRNA mediated by tRNA sequences in mouse cells (Articolo in rivista)

Type
Label
  • Splicing of mRNA mediated by tRNA sequences in mouse cells (Articolo in rivista) (literal)
Anno
  • 2009-01-01T00:00:00+01:00 (literal)
Http://www.cnr.it/ontology/cnr/pubblicazioni.owl#doi
  • 10.1261/rna.1841609 (literal)
Alternative label
  • Zamboni M; Scarabino D; Tocchini-Valentini GP (2009)
    Splicing of mRNA mediated by tRNA sequences in mouse cells
    in RNA (Camb., Print); Cambridge University Press, Cambridge (Regno Unito)
    (literal)
Http://www.cnr.it/ontology/cnr/pubblicazioni.owl#autori
  • Zamboni M; Scarabino D; Tocchini-Valentini GP (literal)
Pagina inizio
  • 2122 (literal)
Pagina fine
  • 2128 (literal)
Http://www.cnr.it/ontology/cnr/pubblicazioni.owl#url
  • http://rnajournal.cshlp.org (literal)
Http://www.cnr.it/ontology/cnr/pubblicazioni.owl#numeroVolume
  • 15 (literal)
Rivista
Http://www.cnr.it/ontology/cnr/pubblicazioni.owl#pagineTotali
  • 7 (literal)
Http://www.cnr.it/ontology/cnr/pubblicazioni.owl#descrizioneSinteticaDelProdotto
  • Pubblicazione su rivista internazionale (literal)
Note
  • PubMe (literal)
Http://www.cnr.it/ontology/cnr/pubblicazioni.owl#affiliazioni
  • IBC-CNR (literal)
Titolo
  • Splicing of mRNA mediated by tRNA sequences in mouse cells (literal)
Abstract
  • tRNA splicing is essential for the formation of tRNAs and therefore for gene expression. A circularly permuted sequence of an amber-suppressor pre-tRNA gene was inserted into the sequence encoding the mouse NEMO protein. We demonstrated that, in mouse cells, the hybrid pre-tRNA/pre-mRNAs can be spliced precisely at the sites of the pre-tRNA intron. This splicing reaction produces functional tRNAs that suppress amber codons as well as translatable mRNAs that sustain the NF-kappaB activation pathway. The RNA molecules extracted from mouse cells were amplified by RT-PCR, and their sequences were determined, confirming the identity of the splice junctions. We then applied the Archaea-express technology, in which an archaeal RNA endonuclease is expressed in mouse cells. We show that both the endogenous eukaryal endonuclease and the archaeal one cleave the hybrid pre-tRNA/pre-mRNAs in the same manner with an additive effect. (literal)
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