http://www.cnr.it/ontology/cnr/individuo/prodotto/ID4159
The tumor suppressor activity of IKK-alpha in stratified epithelia is exerted in part via the TGF-beta antiproliferative pathway (Articolo in rivista)
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- Label
- The tumor suppressor activity of IKK-alpha in stratified epithelia is exerted in part via the TGF-beta antiproliferative pathway (Articolo in rivista) (literal)
- Anno
- 2008-01-01T00:00:00+01:00 (literal)
- Alternative label
Marinari B., Moretti F., Botti E., Giustizieri M.L., Descargues P., Giunta A., Stolfi C., Ballarò C., Papoutsaki M., Alemà S., Monteleone G., Chimienti S., Karin M. and Costanzo A. (2008)
The tumor suppressor activity of IKK-alpha in stratified epithelia is exerted in part via the TGF-beta antiproliferative pathway
in Proceedings of the National Academy of Sciences of the United States of America
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- Marinari B., Moretti F., Botti E., Giustizieri M.L., Descargues P., Giunta A., Stolfi C., Ballarò C., Papoutsaki M., Alemà S., Monteleone G., Chimienti S., Karin M. and Costanzo A. (literal)
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- Titolo
- The tumor suppressor activity of IKK-alpha in stratified epithelia is exerted in part via the TGF-beta antiproliferative pathway (literal)
- Abstract
- The transforming growth factor type beta-1 (TGF-beta) signaling pathway is a major tumor suppressor during early carcinogenesis, and its growth-suppressive activity is commonly lost during early tumor progression. IkappaB kinase alpha (IKKalpha) also acts as a tumor suppressor in stratified epithelia, and its expression and nuclear localization are progressively down-regulated during malignant progression of squamous cell carcinoma (SCC) and acquisition of an invasive phenotype. A critical role for IKKalpha in TGF-beta signaling in stratified epithelia was identified recently during normal keratinocyte differentiation, and both IKKalpha and components of the TGF-beta signaling pathway are required for induction of antiproliferative Myc antagonists in such cells. We now describe that the interaction between IKKalpha and the TGF-beta signaling pathway is also important in a subset of SCCs. In SCCs that are unable to shuttle IKKalpha to the nucleus, defective TGF-beta-induced growth arrest was rescued by introduction of a constitutively nuclear IKKalpha variant. These results suggest that the tumor-suppressive activity of IKKalpha in stratified epithelia may be exerted in part via the TGF-beta signaling pathway. (literal)
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