Evaluation of the toxicity of PAH mixtures and organic extract from Apulian particulate matter by the model system (Articolo in rivista)

Type
Label
  • Evaluation of the toxicity of PAH mixtures and organic extract from Apulian particulate matter by the model system (Articolo in rivista) (literal)
Anno
  • 2010-01-01T00:00:00+01:00 (literal)
Alternative label
  • Daresta B.E., Liuzzi V.C., De Gennaro G., De Giorgi C., De Luca F. and Caselli M. (2010)
    Evaluation of the toxicity of PAH mixtures and organic extract from Apulian particulate matter by the model system
    in Fresenius environmental bulletin
    (literal)
Http://www.cnr.it/ontology/cnr/pubblicazioni.owl#autori
  • Daresta B.E., Liuzzi V.C., De Gennaro G., De Giorgi C., De Luca F. and Caselli M. (literal)
Pagina inizio
  • 2002 (literal)
Pagina fine
  • 2005 (literal)
Http://www.cnr.it/ontology/cnr/pubblicazioni.owl#numeroVolume
  • 19 (literal)
Rivista
Note
  • ISI Web of Science (WOS) (literal)
Http://www.cnr.it/ontology/cnr/pubblicazioni.owl#affiliazioni
  • Barbara E. Daresta, Gianluigi de Gennaro, Maurizio Caselli: University of Bari, Department of Chemistry. Vania C. Liuzzi, Carla De Giorgi: University of Bari, Department of Biochemistry and Molecular Biology. (literal)
Titolo
  • Evaluation of the toxicity of PAH mixtures and organic extract from Apulian particulate matter by the model system (literal)
Abstract
  • In this preliminary work the toxic activity of Polycyclic Aromatic Hydrocarbons (PAHs) mix standard solutions was studied using \"Caenorhabditis elegans\" (C. eleguns) as system for biological studies.The nematode cultures were exposed for 3 days to 0.01, 0.1 and 1 ppb (nglml) of PAH Mix and even if no morphological alterations were observed on the C. elegans populations, the lethality was about 50% when the PAHs concentrations were equal to 0.1 and 1 ppb. Moreover, the lethality test was performed using an organic extract from a PM10 sample.When the gene expression pattern was analyzed a down regulation of the expression on all the genes considered was observed, indicating that the genotoxic effect was scattered on the entire transcription mechanism.These results indicate that \"C, elegans\" is an effective model for the study of PAHs toxicity; future studies will be oriented to the toxicity evaluation of extracts from PM2.5 and PM10 samples collected in Apulia cities. (literal)
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