http://www.cnr.it/ontology/cnr/individuo/prodotto/ID4117
RESISTANCE TO GEMCITABINE IN A LYMPHOMA CELL LINE RESISTANT TO FAS-MEDIATED APOPTOSIS (Articolo in rivista)
- Type
- Label
- RESISTANCE TO GEMCITABINE IN A LYMPHOMA CELL LINE RESISTANT TO FAS-MEDIATED APOPTOSIS (Articolo in rivista) (literal)
- Anno
- 2004-01-01T00:00:00+01:00 (literal)
- Alternative label
Meli M, Tolomeo M, D'Alessandro N, Grimaudo S, Notarbartolo M, Papoff G, Ruberti G, Rausa L, Dusonchet L. (2004)
RESISTANCE TO GEMCITABINE IN A LYMPHOMA CELL LINE RESISTANT TO FAS-MEDIATED APOPTOSIS
in Anticancer research
(literal)
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- Meli M, Tolomeo M, D'Alessandro N, Grimaudo S, Notarbartolo M, Papoff G, Ruberti G, Rausa L, Dusonchet L. (literal)
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- Note
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- Titolo
- RESISTANCE TO GEMCITABINE IN A LYMPHOMA CELL LINE RESISTANT TO FAS-MEDIATED APOPTOSIS (literal)
- Abstract
- BACKGROUND: The T-cell lymphoma cell line HuT78B1, selected for resistance to Fas-mediated apoptosis, resulted unexpectedly resistant to the apoptotic and cytotoxic effects of gemcitabine (dFdC). We investigated whether this resistance was due to the impairment of the Fas/Fas-ligand (FasL) system. MATERIALS AND METHODS: dFdC effects were studied in HuT78B1 and in the parental Fas-sensitive HuT78 cells exposed to inhibitors of the Fas/FasL system. RESULTS: FasL- and Fas-blocking antibodies did not interfere with dFdC-induced apoptosis in HuT78 cells, whereas inhibitors of caspase-8, -9, -1 or -3 had partial inhibitory effects. Notably, in HuT78B1 cells there was a markedly reduced dFdC accumulation notwithstanding a high activity of the activating enzyme deoxycytidine kinase. dFdC accumulation in HuT78 cells was unaffected by a Fas-blocking antibody. CONCLUSION: This is the first time that the selection of a Fas-resistant cell line led to the isolation of a cell clone unable to accumulate the deoxycytidine analog dFdC. Our results show that this alteration is independent from the impairment of the Fas/FasL system. (literal)
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