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Reduced cumulative incidence of diabetes but not insulitis following administration of chimeric human IL-15-murine IgG2b in NOD mice (Articolo in rivista)
- Type
- Label
- Reduced cumulative incidence of diabetes but not insulitis following administration of chimeric human IL-15-murine IgG2b in NOD mice (Articolo in rivista) (literal)
- Anno
- 2003-01-01T00:00:00+01:00 (literal)
- Http://www.cnr.it/ontology/cnr/pubblicazioni.owl#doi
- 10.1002/dmrr.400 (literal)
- Alternative label
Signore A, Annovazzi A, Giacalone P, Beales PE, Valorani MG, Vestri AR, Ruberti G, Manfrini S, Pozzilli P, Bulfone-Paus S. (2003)
Reduced cumulative incidence of diabetes but not insulitis following administration of chimeric human IL-15-murine IgG2b in NOD mice
in Diabetes/metabolism research and reviews (Online)
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- Http://www.cnr.it/ontology/cnr/pubblicazioni.owl#autori
- Signore A, Annovazzi A, Giacalone P, Beales PE, Valorani MG, Vestri AR, Ruberti G, Manfrini S, Pozzilli P, Bulfone-Paus S. (literal)
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- Pubblicazione su rivista scientifica (literal)
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- Titolo
- Reduced cumulative incidence of diabetes but not insulitis following administration of chimeric human IL-15-murine IgG2b in NOD mice (literal)
- Abstract
- BACKGROUND: It has been recently demonstrated that apoptosis is involved in beta-cell destruction in the NOD mouse
model of diabetes. The aim of the present study was to investigate whether IL-15, a cytokine involved in the modulation of
the apoptotic process, is capable of modifying the natural history of diabetes and/or insulitis in pre-diabetic NOD mice. The
rationale for the use of IL-15-IgG2b recombinant cytokine is related to its long half-life (28 +/- 4 h). METHODS: At 10
weeks of age, 2 groups of 24 female mice were treated with single or multiple i.p. doses of IL-15-IgG2b respectively. As
control, 2 groups of 24 age- and litter-matched female mice were injected intra-peritoneally with single or multiple doses of
insulitis were observed in all treated and control mice. CONCLUSIONS: We conclude that IL-15-IgG2b reduces the cumulative incidence
of diabetes, without affecting the extent and severity of the insulitis process. Considering this and the well-defined
anti-apoptotic effects of IL-15, we suggest that the reduction of diabetes incidence could be due to a down-regulation of
beta-cell apoptosis. Copyright 2003 John Wiley & Sons, Ltd. (literal)
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