http://www.cnr.it/ontology/cnr/individuo/prodotto/ID4081
Association of DRB1*04-0301 haplotype and lack of association of two polymorphic sites at CTLA-4 gene with Hashimoto?s thyroiditis in a Italian population. (Articolo in rivista)
- Type
- Label
- Association of DRB1*04-0301 haplotype and lack of association of two polymorphic sites at CTLA-4 gene with Hashimoto?s thyroiditis in a Italian population. (Articolo in rivista) (literal)
- Anno
- 2001-01-01T00:00:00+01:00 (literal)
- Alternative label
Petrone A., Giorgi G., Mesturino C.A., Capizzi M., Cascino I., Nisticò L., Osborn J., Di Mario U., Buzzetti R. (2001)
Association of DRB1*04-0301 haplotype and lack of association of two polymorphic sites at CTLA-4 gene with Hashimoto?s thyroiditis in a Italian population.
in Thyroid (N.Y.N.Y.)
(literal)
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- Petrone A., Giorgi G., Mesturino C.A., Capizzi M., Cascino I., Nisticò L., Osborn J., Di Mario U., Buzzetti R. (literal)
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- ISI Web of Science (WOS) (literal)
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- Titolo
- Association of DRB1*04-0301 haplotype and lack of association of two polymorphic sites at CTLA-4 gene with Hashimoto?s thyroiditis in a Italian population. (literal)
- Abstract
- Hashimoto's thyroiditis (HT) is an autoimmune disease resulting from a complex interaction between genetic and
environmental factors. The genetic loci conferring susceptibility need to be still defined. The aim of the present study was
to determine whether Cytotoxic T-Lymphocyte-Associated Antigen-4 (CTLA-4), HLA DRB1, and DQB1 genes were
associated to HT in an Italian population. We evaluated the allele distribution of the following loci: CTLA-4 exon 1
A49G dimorphism, which resulted in an amino acidic exchange (Thr/Ala) in the leader peptide, CTLA-4 3' microsatellite,
HLA DRB1 and DQB1 in 126 patients with HT and in 301 control subjects from an Italian population (Lazio region).
CTLA-4 exon 1 A49G dimorphism was typed by Polymerase Chain Reaction and Restriction Fragment Length
Polymorphism (PCR-RFLP); CTLA-4 3' microsatellite alleles were defined using a fluorescence-based method. HLA
DRB1 and DQB1 alleles were typed using a SSO reverse line blot method and a probeless procedure based on allele
group-specific amplification followed by DNA heteroduplex analysis, respectively. Data were initially analyzed by chi2
test or Fisher's exact test. Multiple logistic regression analysis was then applied on factors with significant crude odds
ratios and on CTLA-4 exon 1 A49G dimorphism to investigate their independent effects. The two polymorphic sites at
CTLA-4 gene did not increase the risk for HT. The distribution of HLA DRB1 and DQB1 alleles did not show any
significant difference between patients and controls, however, the DRB1*04-DQB1*0301 haplotype was significantly
increased in patients. Other factors that increase the risk of disease were gender and age. Females showed approximately
18 times more risk than males; subjects older than 50 years had an odds ratio of 6.6. These data suggest that these two
polymorphic sites at CTLA-4 do not play a major role in the susceptibility of the disease in an Italian population while
female gender, age over 50 years, HLA DRB1*04-DQB1*0301 haplotype increase the risk of developing HT. (literal)
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