http://www.cnr.it/ontology/cnr/individuo/prodotto/ID4073
Cleavage of non-tRNA substrates by eukaryal tRNA splicing endonucleases (Articolo in rivista)
- Type
- Label
- Cleavage of non-tRNA substrates by eukaryal tRNA splicing endonucleases (Articolo in rivista) (literal)
- Anno
- 2001-01-01T00:00:00+01:00 (literal)
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- Http://www.cnr.it/ontology/cnr/pubblicazioni.owl#autori
- Fruscoloni P., Baldi M.I.,Tocchini-Valentini G.P. (literal)
- Pagina inizio
- Pagina fine
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- Pubblicazione su rivista internazionale (literal)
- Note
- ISI Web of Science (WOS) (literal)
- Http://www.cnr.it/ontology/cnr/pubblicazioni.owl#affiliazioni
- CNR-Istituto di Biologia Cellulare (literal)
- Titolo
- Cleavage of non-tRNA substrates by eukaryal tRNA splicing endonucleases (literal)
- Abstract
- Eukaryal tRNA splicing endonucleases use the mature domains of pre-tRNAs as their primary recognition elements.
However, they can also cleave in a mode that is independent of the mature domain, when substrates are able to form the
bulge-helix-bulge structure (BHB), which is cleaved by archaeal tRNA endonucleases. We present evidence that the eukaryal
enzymes cleave their substrates after forming a structure that resembles the BHB. Consequently, these enzymes can cleave
substrates that lack the mature domain altogether. That raises the possibility that these enzymes could also cleave non-tRNA
substrates that already have a BHB. As predicted, they can do so, both in vitro and in vivo. (literal)
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