Boronophenylalanine uptake in C6-glioma model is dramatically increased by L-DOPA preloading (Articolo in rivista)

Type

• Prodotto della ricerca (Classe)
• Articolo in rivista (Classe)

Label

• Boronophenylalanine uptake in C6-glioma model is dramatically increased by L-DOPA preloading (Articolo in rivista) (literal)

Anno

• 2009-01-01T00:00:00+01:00 (literal)

Http://www.cnr.it/ontology/cnr/pubblicazioni.owl#doi

• 10.1016/j.apradiso.2009.03.017 (literal)

Alternative label

• Capuani, S.; Gili, T.; Bozzali, M.; Russo, S.; Porcari, P.; Cametti, C.; Muolo, M.; D’Amore, E.; Maraviglia, B.; Lazzarino, G.; Pastore, F.S. (2009)
  Boronophenylalanine uptake in C6-glioma model is dramatically increased by L-DOPA preloading
  in Applied radiation and isotopes
  (literal)

Http://www.cnr.it/ontology/cnr/pubblicazioni.owl#autori

• Capuani, S.; Gili, T.; Bozzali, M.; Russo, S.; Porcari, P.; Cametti, C.; Muolo, M.; D’Amore, E.; Maraviglia, B.; Lazzarino, G.; Pastore, F.S. (literal)

Pagina inizio

• S34 (literal)

Http://www.cnr.it/ontology/cnr/pubblicazioni.owl#numeroVolume

• 67 (literal)

Rivista

• Applied radiation and isotopes (Rivista)

Note

• ISI Web of Science (WOS) (literal)

Http://www.cnr.it/ontology/cnr/pubblicazioni.owl#affiliazioni

• CNR Physics Dpt Sapienza IRCCS Santa Lucia foundation Dip of Neurosurgery, Tor Vergata University (literal)

Titolo

• Boronophenylalanine uptake in C6-glioma model is dramatically increased by L-DOPA preloading (literal)

Abstract

• One of the main limitations for BNCT effectiveness is the insufficient intake of (10)B nuclei within turnout cells. This work was aimed at investigating the use Of L-DOPA as enhancer for boronophenylalanine (BPA) uptake in the C6 glioma model. The investigation was first performed in vitro, and then extended in vivo to the animal model. BPA accumulation in C6 glioma cells was assessed, using radiowave dielectric spectroscopy (RDS), with and without L-DOPA preloading. C6 glioma cells were also implanted in the brain of 25 rats, randomly assigned to two experimental branches: (1) intra-carotid BPA infusion; (2) intra-carotid BPA infusion after pre-treatment with L-DOPA, administrated 24 h before BPA infusion. All animals were sacrificed, and assessment of BPA concentrations in turnout tissue, normal brain, and blood samples was performed using high performance liquid chromatography (HPLC). L-DOPA preloading induced a massive increase of BPA concentration either in vitro on C6 glioma cells or in vivo in the animal model tumour. Moreover, no significant difference was found in the normal brain and blood samples between the two animal groups. This study suggests the potential use of L-DOPA as enhancer for EIPA accumulation in malignant gliomas eligible for BNCT. (literal)

Prodotto di

• Institute for chemical and physical processes (IPCF) (Istituto)
• MD.P01.024.001 Dinamica dei sistemi disordinati: materia soffice e biologica (MD.P01.024.002) (Modulo)

Autore CNR

• SILVIA CAPUANI (Persona)

Incoming links:

Prodotto

• Institute for chemical and physical processes (IPCF) (Istituto)
• MD.P01.024.001 Dinamica dei sistemi disordinati: materia soffice e biologica (MD.P01.024.002) (Modulo)

Autore CNR di

• SILVIA CAPUANI (Persona)

Http://www.cnr.it/ontology/cnr/pubblicazioni.owl#rivistaDi

• Applied radiation and isotopes (Rivista)