Influence of Amide versus Ester Linkages on the Properties of Eight-Armed PEG-PLA Star Block Copolymer Hydrogels (Articolo in rivista)

Type
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  • Influence of Amide versus Ester Linkages on the Properties of Eight-Armed PEG-PLA Star Block Copolymer Hydrogels (Articolo in rivista) (literal)
Anno
  • 2010-01-01T00:00:00+01:00 (literal)
Http://www.cnr.it/ontology/cnr/pubblicazioni.owl#doi
  • 10.1021/bm901080d (literal)
Alternative label
  • Sytze J. Buwalda; Pieter J. Dijkstra; Lucia Calucci; Claudia Forte; Jan Feijen (2010)
    Influence of Amide versus Ester Linkages on the Properties of Eight-Armed PEG-PLA Star Block Copolymer Hydrogels
    in Biomacromolecules; ACS, American chemical society, Washington, DC (Stati Uniti d'America)
    (literal)
Http://www.cnr.it/ontology/cnr/pubblicazioni.owl#autori
  • Sytze J. Buwalda; Pieter J. Dijkstra; Lucia Calucci; Claudia Forte; Jan Feijen (literal)
Pagina inizio
  • 224 (literal)
Pagina fine
  • 232 (literal)
Http://www.cnr.it/ontology/cnr/pubblicazioni.owl#url
  • http://pubs.acs.org/doi/abs/10.1021/bm901080d (literal)
Http://www.cnr.it/ontology/cnr/pubblicazioni.owl#numeroVolume
  • 11 (literal)
Rivista
Note
  • ISI Web of Science (WOS) (literal)
Http://www.cnr.it/ontology/cnr/pubblicazioni.owl#affiliazioni
  • Department of Polymer Chemistry and Biomaterials, Faculty of Science and Technology, MIRA Institute for Biomedical Technology and Technical Medicine, University of Twente, P.O. Box 217, 7500 AE Enschede,The Netherlands Istituto per i Processi Chimico-Fisici del CNR, Area della Ricerca di Pisa, via G. Moruzzi 1, 56124 Pisa, Italy (literal)
Titolo
  • Influence of Amide versus Ester Linkages on the Properties of Eight-Armed PEG-PLA Star Block Copolymer Hydrogels (literal)
Abstract
  • Water-soluble eight-armed poly(ethylene glycol)-poly(L-lactide) star block copolymers linked by an amide or ester group between the PEG core and the PLA blocks (PEG-(NHCO)-(PLA)8 and PEG-(OCO)-(PLA)8) were synthesized by the stannous octoate catalyzed ring-opening polymerization of L-lactide using an amine- or hydroxylterminated eight-armed star PEG. At concentrations above the critical gel concentration, thermosensitive hydrogels were obtained, showing a reversible single gel-to-sol transition. At similar composition PEG-(NHCO)-(PLA)8 hydrogels were formed at significantly lower polymer concentrations and had higher storage moduli. Whereas the hydrolytic degradation/dissolution of the PEG-(OCO)-(PLA)8 takes place by preferential hydrolysis of the ester bond between the PEG and PLA block, the PEG-(NHCO)-(PLA)8 hydrogels degrade through hydrolysis of ester bonds in the PLA main chain. Because of their relatively good mechanical properties and slow degradation in vitro, PEG-(NHCO)-(PLA)8 hydrogels are interesting materials for biomedical applications such as controlled drug delivery systems and matrices for tissue engineering. (literal)
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