http://www.cnr.it/ontology/cnr/individuo/prodotto/ID40240
Amphiphilic Cyclodextrins as Nanocarriers of Genistein: A Spectroscopic Investigation Pointing Out the Structural Properties of the Host/Drug Complex System (Articolo in rivista)
- Type
- Label
- Amphiphilic Cyclodextrins as Nanocarriers of Genistein: A Spectroscopic Investigation Pointing Out the Structural Properties of the Host/Drug Complex System (Articolo in rivista) (literal)
- Anno
- 2010-01-01T00:00:00+01:00 (literal)
- Http://www.cnr.it/ontology/cnr/pubblicazioni.owl#doi
- 10.1002/jps.22065 (literal)
- Alternative label
- Http://www.cnr.it/ontology/cnr/pubblicazioni.owl#autori
- R. Stancanelli; M. Guardo; C. Cannava; G. Guglielmo; P. Ficarra; V. Villari; N. Micali; A. Mazzaglia (literal)
- Pagina inizio
- Pagina fine
- Http://www.cnr.it/ontology/cnr/pubblicazioni.owl#numeroVolume
- Rivista
- Note
- ISI Web of Science (WOS) (literal)
- Http://www.cnr.it/ontology/cnr/pubblicazioni.owl#affiliazioni
- Dipartimento Farmaco-Chimico, Universita` di Messina, V.le Annunziata, 98168 Messina, Italy
CNR-Istituto per i Processi Chimico-Fisici, sede di Messina, Contrada Papardo, Salita Sperone, Faro Superiore, 98158 Messina, Italy
CNR-Istituto per lo studio dei Materiali Nanostrutturati, Messina, Salita Sperone 31, 98166 Messina, Italy (literal)
- Titolo
- Amphiphilic Cyclodextrins as Nanocarriers of Genistein: A Spectroscopic Investigation Pointing Out the Structural Properties of the Host/Drug Complex System (literal)
- Abstract
- Nanoggregates of nonionic amphiphilic cyclodextrin (ACyD) modified with hydrophobic
chains of intermediate length [(2-oligo-ethyleneoxide-6-hexylthio)-b-CyD, SC6OH] were
prepared by emulsification-diffusion method. They are able to entrap an isoflavone, genistein
(Gen), and the complexed species are studied at different host/guest molar ratio. The increased
isoflavone solubility in the presence of the aggregates of SC6OH is investigated by UV-Vis
spectroscopy, whereas size, charge, and structure of aggregates and their complexes with Gen
are measured by means of static and quasi-elastic light scattering, and electrophoretic mobility
measurements. On the other hand, preparing samples by the conventional method used for
liposomes (hydration of an organic film of SC6OH and sonication) gives rise to aggregates with
different sizes and lower colloidal stability. It is shown that the improved stability in water of
ACyD aggregates both in the absence and in the presence of Gen, obtained by emulsification-
diffusion is due to the existence of nanodomains of organic solvent (RHffi120 nm) which cannot
be completely removed by evaporation and freeze-drying and in which host/guest complexes are
contained. This result shows that residues of organic solvent from preparation step favor the
colloidal stability of the aggregate, but their presence must be taken into account in designing
systems for drug delivery (literal)
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