The rutin/beta-cyclodextrin interactions in fully aqueous solution: spectroscopic studies and biological assays (Articolo in rivista)

Type
Label
  • The rutin/beta-cyclodextrin interactions in fully aqueous solution: spectroscopic studies and biological assays (Articolo in rivista) (literal)
Anno
  • 2005-01-01T00:00:00+01:00 (literal)
Http://www.cnr.it/ontology/cnr/pubblicazioni.owl#doi
  • 10.1016/j.jpba.2004.09.018 (literal)
Alternative label
  • M.L. Calabrò; S. Tommasini; P. Donato; R. Stancanelli; D. Raneri; S. Catania; C. Costa; V. Villari; P. Ficarra; R. Ficarra (2005)
    The rutin/beta-cyclodextrin interactions in fully aqueous solution: spectroscopic studies and biological assays
    in Journal of pharmaceutical and biomedical analysis (Print)
    (literal)
Http://www.cnr.it/ontology/cnr/pubblicazioni.owl#autori
  • M.L. Calabrò; S. Tommasini; P. Donato; R. Stancanelli; D. Raneri; S. Catania; C. Costa; V. Villari; P. Ficarra; R. Ficarra (literal)
Pagina inizio
  • 1019 (literal)
Pagina fine
  • 1027 (literal)
Http://www.cnr.it/ontology/cnr/pubblicazioni.owl#numeroVolume
  • 36 (literal)
Rivista
Http://www.cnr.it/ontology/cnr/pubblicazioni.owl#numeroFascicolo
  • 5 (literal)
Note
  • ISI Web of Science (WOS) (literal)
Http://www.cnr.it/ontology/cnr/pubblicazioni.owl#affiliazioni
  • Dipartimento Farmaco–Chimico, Facoltà di Farmacia, Università di Messina, Viale Annunziata, 98168 Messina, ME, Italy Medicina del Lavoro, Policlinico Universitario, Via Consolare Valeria 1, 98125 Messina, ME, Italy Dipartimento Farmaco–Biologico, Facoltà di Farmacia, Università di Messina, Viale Annunziata, 98168 Messina, ME, Italy CNR, Istituto per i Processi Chimico-Fisici, IPCF-CNR, Via La Farina 237, 98123 Messina, ME, Italy (literal)
Titolo
  • The rutin/beta-cyclodextrin interactions in fully aqueous solution: spectroscopic studies and biological assays (literal)
Abstract
  • In the presentwork the feasibility of beta-cyclodextrin complexationwas explored, as a tool for improving the aqueous solubility and antioxidant efficacy of rutin. By means of 1H NMR, UV–vis and circular dichroism spectroscopy the single aromatic ring of rutin was found to be inserted into the beta-cyclodextrin cavity to form a 1:1 inclusion complex. The effect of beta-cyclodextrin on the spectral features of rutin was quantitatively investigated, in fully aqueous medium, by holding the concentration of the guest constant and varying the host concentration. The associated binding constants were estimated to be 142 and 153 1/M, respectively, on the basis of the observed UV–vis absorption and circular dichroism intensities. The antioxidant activity of rutin was also investigated, as affected by molecular encapsulation within beta-cyclodextrin (batophenanthroline test; comet assay; lipid peroxidation); the inclusion complex revealed improved antioxidant efficacy that may be in part explained by an increased solubility in the biological moiety. (literal)
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