http://www.cnr.it/ontology/cnr/individuo/prodotto/ID39559

Study of the aggregation of insulin glargine by light scattering (Articolo in rivista)

Type

Label

Study of the aggregation of insulin glargine by light scattering (Articolo in rivista) (literal)

Anno

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Alternative label

R. Coppolino, S. Coppolino, V. Villari (2006)
Study of the aggregation of insulin glargine by light scattering
in Journal of pharmaceutical sciences
(literal)

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Pagina inizio

Pagina fine

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Rivista

Note

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PhD in T.E.P.P.S.A., University of Messina, Piazza Pugliatti, 98122 Messina, Italy Azienda U.S.L. 5 Hospital Barone I. Romeo, via Mazzini 5, 98066 Patti, Messina, Italy CNR-Istituto per i Processi Chimico-Fisici, Sez. Messina, Via La Farina 237, 98123 Messina, Italy (literal)

Titolo

Abstract

Insulin glargine (Lantus1, Aventis Pharma, Deutschland, GmbH) is a new long-acting human insulin analog. Structural modification of the insulin molecule at two sites alters its pH, causing insulin glargine to precipitate in the neutral environment of subcutaneous tissue and to form a depot that is slowly absorbed into the bloodstream. In this paper insulin glargine aggregation is investigated by light scattering. This study shows that, in a physiologic-like pH (even at low ionic strength) conditions, aggregation phenomena occur, giving rise to compact structures with radius of hundreds of nanometers. The aggregation of insulin glargine can be responsible for its slow in situ absorption allowing for a more controlled release. (literal)

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