http://www.cnr.it/ontology/cnr/individuo/prodotto/ID38987
Enriched environment and acceleration of visual system development. (Articolo in rivista)
- Type
- Label
- Enriched environment and acceleration of visual system development. (Articolo in rivista) (literal)
- Anno
- 2004-01-01T00:00:00+01:00 (literal)
- Http://www.cnr.it/ontology/cnr/pubblicazioni.owl#doi
- 10.1016/j.neuropharm.2004.07.008 (literal)
- Alternative label
Sale A, Putignano E, Cancedda L, Landi S, Cirulli F, Berardi N, Maffei L. (2004)
Enriched environment and acceleration of visual system development.
in Neuropharmacology
(literal)
- Http://www.cnr.it/ontology/cnr/pubblicazioni.owl#autori
- Sale A, Putignano E, Cancedda L, Landi S, Cirulli F, Berardi N, Maffei L. (literal)
- Pagina inizio
- Pagina fine
- Rivista
- Note
- ISI Web of Science (WOS) (literal)
- Http://www.cnr.it/ontology/cnr/pubblicazioni.owl#affiliazioni
- Institute of Neuroscience CNR, via Moruzzi 1, 56100 Pisa (literal)
- Titolo
- Enriched environment and acceleration of visual system development. (literal)
- Abstract
- Rearing mice from birth in an enriched environment leads to a conspicuous acceleration of visual system development appreciable
at behavioral, electrophysiological andmolecular level. Little is known about the possible mechanisms of action through
which enriched environment affects visual system development. It has been suggested that differences in maternal behavior
between enrichedand non-enrichedcond itions could contribute to the earliest effects of enrichedenvironment on visual development
andthat neurotrophins, BDNF in particular, might be involved. Here, we examined Brain Derived Neurotrophic Factor
(BDNF) levels in the visual cortex during development and showed that an increase occurs in the first week of life in enriched
pups comparedto standardrearedpups; BDNF levels at birth were equal in the two groups. This suggests a postnatal rather
than a prenatal effect of environment on BDNF. A detailed analysis of maternal care behavior showed that pups raised in a condition
of social andphysical enrichment experiencedhigher levels of licking behavior andphysical contact comparedto standard
reared pups and that enhanced levels of licking were also provided to pups in an enriched environment where no adult females
other than the mother were present. Thus, different levels of maternal care in different environmental conditions could act as
indirect mediator for the earliest effects of enrichment on visual system development.
Some of the effects of different levels of maternal care on the offspring behavior are long lasting. We measured the visual acuity
of differentially reared mice at the end of the period of visual acuity development (postnatal day 45) and at 12 months of age,
using a behavioral discrimination task. We found better learning abilities and higher visual acuity in enriched compared to standard
reared mice at both ages. (literal)
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- Autore CNR
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