http://www.cnr.it/ontology/cnr/individuo/prodotto/ID38935
Down-regulation of hippocampal BDNF and Arc associated with improvement in aversive spatial memory performance in socially isolated rats. (Articolo in rivista)
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- Down-regulation of hippocampal BDNF and Arc associated with improvement in aversive spatial memory performance in socially isolated rats. (Articolo in rivista) (literal)
- Anno
- 2011-01-01T00:00:00+01:00 (literal)
- Http://www.cnr.it/ontology/cnr/pubblicazioni.owl#doi
- 10.1016/j.bbr.2011.03.021 (literal)
- Alternative label
Pisu M.G., Dore R., Mostallino M.C., Loi M., Pibiri F., Mameli R., Cadeddu R., Secci P.P., Serra M. (2011)
Down-regulation of hippocampal BDNF and Arc associated with improvement in aversive spatial memory performance in socially isolated rats.
in Behavioural brain research
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- Pisu M.G., Dore R., Mostallino M.C., Loi M., Pibiri F., Mameli R., Cadeddu R., Secci P.P., Serra M. (literal)
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- Http://www.cnr.it/ontology/cnr/pubblicazioni.owl#affiliazioni
- a Department of Experimental Biology, Chair of Pharmacology, University of Cagliari, Cagliari 09100, Italy;
b Center of Excellence for Neurobiology of Dependence, University of Cagliari, Cagliari 09100, Italy;
c C.N.R., Institute of Neuroscience, Cagliari 09100, Italy (literal)
- Titolo
- Down-regulation of hippocampal BDNF and Arc associated with improvement in aversive spatial memory performance in socially isolated rats. (literal)
- Abstract
- Rats deprived of social contact with other rats at a young age experience a form of prolonged stress that
leads to long-lasting changes in behavioral profile. Such isolation is thought to be anxiogenic for these
normally gregarious animals, and the abnormal reactivity of isolated rats to environmental stimuli is
thought to be a product of prolonged stress. We now show that isolation of rats at weaning reduced
immobility time in the forced swim test, decreased sucrose intake and preference, and down-regulated
both brain-derived neurotrophic factor (BDNF) and activity-regulated cytoskeletal associated protein
(Arc) in the hippocampus. In the Morris water maze, isolated rats showed a reduced latency to reach
the hidden platform during training, indicative of an improved learning performance, compared with
group-housed rats. The cumulative search error during place training trials indicated a reliable difference
between isolated and group-housed rats on days 4 and 5. The probe trial revealed a significant decrease
of the average proximity to the target location in the isolated rats suggesting an improvement in spatial
memory.
Isolated rats also showed an increase in the plasma level of corticosterone on the 5th day of training
and increased expression of BDNF and Arc in the hippocampus on both days 1 and 5. These results show
that social isolation from weaning in rats results in development of depressive-like behavior but has a
positive effect on spatial learning, supporting the existence of a facilitating effect of stress on cognitive
function. (literal)
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