Ventral striatal plasticity and spatial memory. (Articolo in rivista)

Type
Label
  • Ventral striatal plasticity and spatial memory. (Articolo in rivista) (literal)
Anno
  • 2010-01-01T00:00:00+01:00 (literal)
Http://www.cnr.it/ontology/cnr/pubblicazioni.owl#doi
  • 10.1073/pnas.0911757107 (literal)
Alternative label
  • Ferretti V, Roullet P, Sargolini F, Rinaldi A, Perri V, Del Fabbro M, Costantini VJ, Annese V, Scesa G, De Stefano ME, Oliverio A, Mele A. (2010)
    Ventral striatal plasticity and spatial memory.
    in Proceedings of the National Academy of Sciences of the United States of America
    (literal)
Http://www.cnr.it/ontology/cnr/pubblicazioni.owl#autori
  • Ferretti V, Roullet P, Sargolini F, Rinaldi A, Perri V, Del Fabbro M, Costantini VJ, Annese V, Scesa G, De Stefano ME, Oliverio A, Mele A. (literal)
Pagina inizio
  • 7945 (literal)
Pagina fine
  • 7950 (literal)
Http://www.cnr.it/ontology/cnr/pubblicazioni.owl#numeroVolume
  • 107 (literal)
Rivista
Note
  • ISI Web of Science (WOS) (literal)
Http://www.cnr.it/ontology/cnr/pubblicazioni.owl#affiliazioni
  • aDipartimento di Genetica e Biologia Molecolare, and bCenter for Research in Neurobiology \"D. Bovet,\" Università di Roma \"La Sapienza\", 00185 Rome, Italy; cCentre de Recherches sur la Cognition Animale, Université Paul Sabatier, Centre National de la Recherche Scientifique-Unité Mixte de Recherche 5169, 31062 Toulouse, France; dLaboratoire de Neurobiologie de la Cognition, Université de Provence, Centre National de la Recherche Scientifique-Unité Mixte de Recherche 6155, 13331 Marseille, France; eIstituto Pasteur-Fondazione Cenci Bolognetti, Dipartimento di Biologia Cellulare e dello Sviluppo, Università di Roma \"La Sapienza\", 00185 Rome, Italy; and fIstituto di Neuroscienze, Consiglio Nazionale delle Ricerche/Centro Europeo per la Ricerca sul Cervello, 00143 Rome, Italy (literal)
Titolo
  • Ventral striatal plasticity and spatial memory. (literal)
Abstract
  • Spatial memory formation is a dynamic process requiring a series of cellular and molecular steps, such as gene expression and protein translation, leading to morphological changes that have been envisaged as the structural bases for the engram. Despite the role suggested for medial temporal lobe plasticity in spatial memory, recent behavioral observations implicate specific components of the striatal complex in spatial information processing. However, the potential occurrence of neural plasticity within this structure after spatial learning has never been investigated. In this study we demonstrate that blockade of cAMP response element binding protein-induced transcription or inhibition of protein synthesis or extracellular proteolytic activity in the ventral striatumimpairs longterm spatial memory. These findings demonstrate that, in the ventral striatum, similarly to what happens in the hippocampus, several key molecular events crucial for the expression of neural plasticity are required in the early stages of spatial memory formation. (literal)
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