Anticancer therapeutics that target selenoenzymes: synthesis, characterization, in vitro cytotoxicity and thioredoxin reductase inhibition of a series of gold(I) complexes containing hydrophilic phosphine ligands (Articolo in rivista)

Type

• Prodotto della ricerca (Classe)
• Articolo in rivista (Classe)

Label

• Anticancer therapeutics that target selenoenzymes: synthesis, characterization, in vitro cytotoxicity and thioredoxin reductase inhibition of a series of gold(I) complexes containing hydrophilic phosphine ligands (Articolo in rivista) (literal)

Anno

• 2010-01-01T00:00:00+01:00 (literal)

Http://www.cnr.it/ontology/cnr/pubblicazioni.owl#doi

• 10.1002/cmdc.200900370 (literal)

Alternative label

• Vergara E, Casini A, Sorrentino F, Zava O, Cerrada E, Rigobello MP, Bindoli A, Laguna M, Dyson PJ. (2010)
  Anticancer therapeutics that target selenoenzymes: synthesis, characterization, in vitro cytotoxicity and thioredoxin reductase inhibition of a series of gold(I) complexes containing hydrophilic phosphine ligands
  in ChemMedChem (Print)
  (literal)

Http://www.cnr.it/ontology/cnr/pubblicazioni.owl#autori

• Vergara E, Casini A, Sorrentino F, Zava O, Cerrada E, Rigobello MP, Bindoli A, Laguna M, Dyson PJ. (literal)

Pagina inizio

• 96 (literal)

Pagina fine

• 102 (literal)

Http://www.cnr.it/ontology/cnr/pubblicazioni.owl#numeroVolume

• 5 (literal)

Rivista

• ChemMedChem (Rivista)

Note

• ISI Web of Science (WOS) (literal)

Http://www.cnr.it/ontology/cnr/pubblicazioni.owl#affiliazioni

• Dr. E. Vergara, Dr. E. Cerrada, Prof. M. Laguna, Departamento de Qu?mica Inorg?nica, Instituto de Ciencia de Materiales de Arag?n Universidad de Zaragoza-CSIC, 50009 Zaragoza (Spain) Dr. A. Casini, Dr. O. Zava, Prof. P. J. Dyson, Institut des Sciences et Ing?nierie Chimiques, Ecole Polytechnique F?d?rale de Lausanne (EPFL), 1015 Lausanne (Switzerland) Dr. F. Sorrentino, Dr. M. P. Rigobello, Dipartimento di Chimica Biologica, Universit? di Padova, Viale G. Colombo 3, 35121 Padova (Italy) Dr. A. Bindoli, Istituto di Neuroscienze (CNR), Sezione di Padova, c/o Dipartimento di Chimica Biologica, Viale G. Colombo 3, 35121 Padova (Italy) (literal)

Titolo

• Anticancer therapeutics that target selenoenzymes: synthesis, characterization, in vitro cytotoxicity and thioredoxin reductase inhibition of a series of gold(I) complexes containing hydrophilic phosphine ligands (literal)

Abstract

• Gold(I) complexes bearing water-soluble phosphine ligands, including 1,3,5-triaza-7-phosphaadamantane (PTA), 3,7-diacetyl-1,3,7-triaza-5-phosphabicyclo[3.3.1]nonane (DAPTA), and sodium triphenylphosphine trisulfonate (TPPTS), in combination with thionate ligands, were screened for their antiproliferative activities against human ovarian cancer cell lines A2780 either sensitive or resistant to cisplatin. In addition, the compounds were screened for their inhibition of mammalian thioredoxin reductases (TrxR), enzymes that are overexpressed in many tumor cells and contribute to drug resistance. The gold(I)-phosphine complexes efficiently inhibited cytosolic and mitochondrial TrxRs at concentrations that did not affect the related oxidoreductase glutathione reductase (GR). Additional complementary information on the enzyme metallation process and potential gold binding sites was obtained through the application of a specific biochemical assay using a thiol-tagging reagent, BIAM (biotin-conjugated iodoacetamide). (literal)

Prodotto di

• Institute of neuroscience (IN) (Istituto)
• Neurobiologia e Neuropatologia (ME.P02.005.001) (Modulo)

Autore CNR

• ALBERTO BINDOLI (Unità di personale interno)

Incoming links:

Autore CNR di

• ALBERTO BINDOLI (Unità di personale interno)

Prodotto

• Institute of neuroscience (IN) (Istituto)
• Neurobiologia e Neuropatologia (ME.P02.005.001) (Modulo)

Http://www.cnr.it/ontology/cnr/pubblicazioni.owl#rivistaDi

• ChemMedChem (Rivista)