http://www.cnr.it/ontology/cnr/individuo/prodotto/ID38838
The mitochondrial permeability transition from yeast to mammals. (Articolo in rivista)
- Type
- Label
- The mitochondrial permeability transition from yeast to mammals. (Articolo in rivista) (literal)
- Anno
- 2010-01-01T00:00:00+01:00 (literal)
- Http://www.cnr.it/ontology/cnr/pubblicazioni.owl#doi
- 10.1016/j.febslet.2010.04.023 (literal)
- Alternative label
- Http://www.cnr.it/ontology/cnr/pubblicazioni.owl#autori
- Azzolin L.; von Stockum S.; Basso E.; Petronilli V.; Forte M.A.; Bernardi P (literal)
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- Http://www.cnr.it/ontology/cnr/pubblicazioni.owl#numeroVolume
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- PubMe (literal)
- ISI Web of Science (WOS) (literal)
- Http://www.cnr.it/ontology/cnr/pubblicazioni.owl#affiliazioni
- Department of Biomedical Sciences, CNR Institute of Neuroscience, University of Padova, Italy /
Vollum Institute, Oregon Health and Sciences University, Portland, OR, USA (literal)
- Titolo
- The mitochondrial permeability transition from yeast to mammals. (literal)
- Abstract
- Regulated permeability changes have been detected in mitochondria across species. We review here their key features, with the goal of assessing whether a \"permeability transition\" similar to that observed in higher eukaryotes is present in other species. The recent discoveries (i) that treatment with cyclosporin A (CsA) unmasks an inhibitory site for inorganic phosphate (Pi) [Basso, E., Petronilli, V., Forte, M. A. and Bernardi, P. (2008) Phosphate is essential for inhibition of the mitochondrial permeability transition pore by cyclosporin A and by cyclophilin D ablation. J. Biol. Chem. 283, 26307-26311], the classical inhibitor of the permeability transition of yeast and (ii) that under proper experimental conditions a matrix Ca(2+)-dependence can be demonstrated in yeast as well [Yamada, A., Yamamoto, T., Yoshimura, Y., Gouda, S., Kawashima, S., Yamazaki, N., Yamashita, K., Kataoka, M., Nagata, T., Terada, H., Pfeiffer, D. R. and Shinohara Y. (2009) Ca(2+)-induced permeability transition can be observed even in yeast mitochondria under optimized experimental conditions. Biochim. Biophys. Acta 1787, 1486-1491] suggest that the mitochondrial permeability transition has been conserved during evolution. (C) 2010 Federation of European Biochemical Societies. Published by Elsevier B.V. All rights reserved. (literal)
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