http://www.cnr.it/ontology/cnr/individuo/prodotto/ID38775

Dyskinetic potential of dopamine agonists is associated with different striatonigral/striatopallidal zif-268 expression (Articolo in rivista)

Type

Articolo in rivista (Classe)
Prodotto della ricerca (Classe)

Label

Dyskinetic potential of dopamine agonists is associated with different striatonigral/striatopallidal zif-268 expression (Articolo in rivista) (literal)

Anno

2010-01-01T00:00:00+01:00 (literal)

Http://www.cnr.it/ontology/cnr/pubblicazioni.owl#doi

10.1016/j.expneurol.2010.04.016 (literal)

Alternative label

Carta, Anna R.; Frau, Lucia; Pinna, Annalisa; Morelli, Micaela (2010)
Dyskinetic potential of dopamine agonists is associated with different striatonigral/striatopallidal zif-268 expression
in Experimental neurology; Elsevier Inc., San Diego (Stati Uniti d'America)
(literal)

Http://www.cnr.it/ontology/cnr/pubblicazioni.owl#autori

Carta, Anna R.; Frau, Lucia; Pinna, Annalisa; Morelli, Micaela (literal)

Pagina inizio

395 (literal)

Pagina fine

402 (literal)

Http://www.cnr.it/ontology/cnr/pubblicazioni.owl#numeroVolume

224 (literal)

Rivista

Experimental neurology (Rivista)

Http://www.cnr.it/ontology/cnr/pubblicazioni.owl#pagineTotali

8 (literal)

Http://www.cnr.it/ontology/cnr/pubblicazioni.owl#numeroFascicolo

2 (literal)

Note

ISI Web of Science (WoS) (literal)

Http://www.cnr.it/ontology/cnr/pubblicazioni.owl#affiliazioni

University of Cagliari; Ctr Excellence Studies Neurobiol Addict; Inst Neurosci CNR (literal)

Titolo

Dyskinetic potential of dopamine agonists is associated with different striatonigral/striatopallidal zif-268 expression (literal)

Abstract

In the dopamine-depleted striatum, an altered post-synaptic signalling of efferent neurons might underline the onset of variable dyskinetic responses to dopaminergic agonists. We have previously shown that a subchronic treatment with the D1 agonist SKF-38393 and the D2 agonist ropinirole induces a dyskinetic response of high and low intensities respectively, in 6-hydroxydopamine-lesioned rats. Here, zif-268 mRNA expression was evaluated in striatonigral and striatopallidal neurons to assess a neurochemical marker of these different dyskinetic responses upon drug administration. Acute and subchronic SKF-38393 (3 mg/kg) increased zif-268 expression per neuron in the striatonigral pathway, albeit the number of neurons displaying high early-gene levels was reduced by the subchronic treatment. Zif-268 mRNA in striatopallidal neurons was not affected by SKF-38393 treatments. In contrast, ropinirole (5 mg/kg) did not alter zif-268 mRNA in striatonigral neurons acutely, whereas ropinirole decreased zif-268 mRNA subchronically. Both acute and subchronic ropinirole decreased zif-268 levels in the striatopallidal pathway. The differential expression of zif-268 in striatonigral and striatopallidal neurons might provide a biochemical correlate of the dyskinetic outcome displayed by SKF-38393 and ropinirole treatments, suggesting that evaluation of neuronal responses upon drug administration provides a tool for the preclinical characterization of dyskinetic potential beyond behavioural tests. (C) 2010 Elsevier Inc. All rights reserved. (literal)

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