Changes induced by formalin pain in central alpha1-adrenoceptor density are modulated by adenosine receptor agonists. (Articolo in rivista)

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  • Changes induced by formalin pain in central alpha1-adrenoceptor density are modulated by adenosine receptor agonists. (Articolo in rivista) (literal)
Anno
  • 2010-01-01T00:00:00+01:00 (literal)
Alternative label
  • Nalepa I, Vetulani J, Borghi V, Kowalska M, PrzewBocka B, Roman A, Pavone F. (2010)
    Changes induced by formalin pain in central alpha1-adrenoceptor density are modulated by adenosine receptor agonists.
    in Journal of neural transmission
    (literal)
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  • Nalepa I, Vetulani J, Borghi V, Kowalska M, PrzewBocka B, Roman A, Pavone F. (literal)
Pagina inizio
  • 549 (literal)
Pagina fine
  • 558 (literal)
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  • 117 (literal)
Rivista
Note
  • ISI Web of Science (WOS) (literal)
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  • Department of Brain Biochemistry, Institute of Pharmacology, Polish Academy of Sciences, 12 Sme ? tna Str, 31-343 Krako ? w, Poland Department of Pharmacology of Pain, Institute of Pharmacology, Polish Academy of Sciences, 12 Sme ? tna Str, 31-343 Krako ? w, Poland CNR, Institute of Neuroscience, 65 del Fosso di Fiorano Str, 00143 Rome, Italy (literal)
Titolo
  • Changes induced by formalin pain in central alpha1-adrenoceptor density are modulated by adenosine receptor agonists. (literal)
Abstract
  • We aimed to elucidate the role of a1-adrenoceptors in adenosine analgesia in the formalin test. Formalin was injected into the hind paw of male CD-1 mice after injection of adenosine A1 or A2a receptor agonists, CPA, [N(6)-cyclopentyladenosine], and CGS21680 [2-p-(2-carboxyethyl) phenylethylamino-50 -N-ethylcarboxam- idoadenosine hydrochloride]. In the behavioral experiment, a1-adrenoceptors were blocked by an a1 adrenoceptor antagonist prazosin, 0.01 mg/kg i.p., and the time mice spent paw licking was recorded for the early (0-15 min) and late (15-60 min) phase of formalin pain. In the neurochemical experiments, mice were killed 15 or 45 min after formalin injection. The density of a1-adrenoceptors was assessed in various brain areas and in the lumbar spinal cord by [3H]prazosin autoradiography. Adenosine agonists produced analgesia in both phases of formalin pain, while prazosin showed a tendency to pronociceptive action in the late phase, and antagonized the effect of CGS21680. After formalin injection, a1-adrenoceptor density was elevated in some brain areas, mainly in the late phase (some contralateral amygdaloid and ipsilateral thalamic nuclei) and depressed in others (early phase in the ipsilateral spinal cord and late phase in both ipsi- and contralateral sensorimotor cortex). Elevation of a1-adrenoceptor density, which may be interpreted as a defensive response, did not develop in several cases of CPA-pretreated mice. This suggests that the analgesic effect of adenosine A1 receptor activation renders the defensive response unnecessary. The depression of a1 adrenoceptors may suggest development of hypersensitivity in a given structure, and this was antagonized by CGS21680, suggesting the role of A2a receptors in control of inflammatory formalin pain. (literal)
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