http://www.cnr.it/ontology/cnr/individuo/prodotto/ID38716
The formation of recent and remote memory is associated with time-dependent formation of dendritic spines in the hippocampus and anterior cingulate cortex (Articolo in rivista)
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- Label
- The formation of recent and remote memory is associated with time-dependent formation of dendritic spines in the hippocampus and anterior cingulate cortex (Articolo in rivista) (literal)
- Anno
- 2009-01-01T00:00:00+01:00 (literal)
- Alternative label
Restivo L, Vetere G, Bontempi B, Ammassari-Teule M (2009)
The formation of recent and remote memory is associated with time-dependent formation of dendritic spines in the hippocampus and anterior cingulate cortex
in The Journal of neuroscience
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- Restivo L, Vetere G, Bontempi B, Ammassari-Teule M (literal)
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- ISI Web of Science (WOS) (literal)
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- Istituto di neuroscienze (literal)
- Titolo
- The formation of recent and remote memory is associated with time-dependent formation of dendritic spines in the hippocampus and anterior cingulate cortex (literal)
- Abstract
- Although hippocampal- cortical interactions are crucial for the formation of enduring declarative memories, synaptic events that govern
long-term memory storage remain mostly unclear. We present evidence that neuronal structural changes, i.e., dendritic spine growth,
develop sequentially in the hippocampus and anterior cingulate cortex (aCC) during the formation of recent and remote contextual fear
memory. We found that mice placed in a conditioning chamber for one 7 min conditioning session and exposed to five footshocks
(duration, 2 s; intensity, 0.7 mA; interstimulus interval, 60 s) delivered through the grid floor exhibited robust fear response when
returned to the experimental context 24 h or 36 d after the conditioning. We then observed that their fear response at the recent, but not
the remote, time point was associated with an increase in spine density on hippocampal neurons, whereas an inverse temporal pattern of
spine density changes occurred on aCC neurons. At each time point, hippocampal or aCC structural alterations were achieved even in the
absence of recent or remote memory tests, thus suggesting that they were not driven by retrieval processes. Furthermore, ibotenic lesions
of the hippocampus impaired remote memory and prevented dendritic spine growth on aCC neurons when they were performed immediately
after the conditioning, whereas they were ineffective when performed 24 d later. These findings reveal that gradual structural
changes modifying connectivity in hippocampal- cortical networks underlie the formation and expression of remote memory, and that
the hippocampus plays a crucial but time-limited role in driving structural plasticity in the cortex. (literal)
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