http://www.cnr.it/ontology/cnr/individuo/prodotto/ID38693
The biocompatibility of amino functionalized CdSe/ZnS quantum-dot-Doped SiO2 nanoparticles with primary neural cells and their gene carrying performance. (Articolo in rivista)
- Type
- Label
- The biocompatibility of amino functionalized CdSe/ZnS quantum-dot-Doped SiO2 nanoparticles with primary neural cells and their gene carrying performance. (Articolo in rivista) (literal)
- Anno
- 2010-01-01T00:00:00+01:00 (literal)
- Alternative label
- Http://www.cnr.it/ontology/cnr/pubblicazioni.owl#autori
- Bardi G; Malvindi MA; Gherardini L; Costa M; Pompa PP; Cingolani R; Pizzorusso T. (literal)
- Pagina inizio
- Pagina fine
- Http://www.cnr.it/ontology/cnr/pubblicazioni.owl#numeroVolume
- Rivista
- Note
- Http://www.cnr.it/ontology/cnr/pubblicazioni.owl#affiliazioni
- Costa Mario: Istituto di Neuroscienze Pisa Lisa Gherardini: Istituto di Fisiologia Clinica Siena (literal)
- Titolo
- The biocompatibility of amino functionalized CdSe/ZnS quantum-dot-Doped SiO2 nanoparticles with primary neural cells and their gene carrying performance. (literal)
- Abstract
- Nanoparticles have an enormous potential for the development of applications in biomedicine such as
gene or drug delivery. We developed and characterized NH2 functionalized CdSe/ZnS quantum dot (QD)-
doped SiO2 nanoparticles (NPs) with both imaging and gene carrier capabilities. We show that QD-doped
SiO2 NPs are internalized by primary cortical neural cells without inducing cell death in vitro and in vivo.
Moreover, the ability to bind, transport and release DNA into the cell allows GFP-plasmid transfection of
NIH-3T3 and human neuroblastoma SH-SY5Y cell lines. QD-doped SiO2 NPs properties make them
a valuable tool for future nanomedicine application. (literal)
- Prodotto di
- Autore CNR
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