http://www.cnr.it/ontology/cnr/individuo/prodotto/ID38682

The positive allosteric modulator of the GABAB receptor, rac-BHFF, suppresses alcohol self-administration (Articolo in rivista)

Type

Prodotto della ricerca (Classe)
Articolo in rivista (Classe)

Label

The positive allosteric modulator of the GABAB receptor, rac-BHFF, suppresses alcohol self-administration (Articolo in rivista) (literal)

Anno

2010-01-01T00:00:00+01:00 (literal)

Http://www.cnr.it/ontology/cnr/pubblicazioni.owl#doi

10.1016/j.drugalcdep.2009.12.019 (literal)

Alternative label

Maccioni P., Thomas A.W., Carai M.A.M., Gessa G.L., Malherbe P., Colombo G (2010)
The positive allosteric modulator of the GABAB receptor, rac-BHFF, suppresses alcohol self-administration
in Drug and Alcohol Dependence; Elsevier Ireland Ltd., Clare (Irlanda)
(literal)

Http://www.cnr.it/ontology/cnr/pubblicazioni.owl#autori

Maccioni P., Thomas A.W., Carai M.A.M., Gessa G.L., Malherbe P., Colombo G (literal)

Pagina inizio

96 (literal)

Pagina fine

103 (literal)

Http://www.cnr.it/ontology/cnr/pubblicazioni.owl#numeroVolume

109 (literal)

Rivista

Drug and Alcohol Dependence (Rivista)

Http://www.cnr.it/ontology/cnr/pubblicazioni.owl#pagineTotali

8 (literal)

Note

Google Scholar (literal)
PubMed (literal)
Scopus (literal)
ISI Web of Science (WOS) (literal)

Http://www.cnr.it/ontology/cnr/pubblicazioni.owl#affiliazioni

Neuroscience Institute, National Research Council of Italy, Section of Cagliari, Italy Discovery Research CNS, F. Hoffmann-La Roche Ltd., Psychiatry Disease Area, Basel, Switzerland (literal)

Titolo

The positive allosteric modulator of the GABAB receptor, rac-BHFF, suppresses alcohol self-administration (literal)

Abstract

The present study was designed to extend to the newly synthesized rac-BHFF [(R,S)-5,7-di-tert-butyl-3-hydroxy-3-trifluoromethyl-3H-benzofuran-2-one] the investigation on the capacity of positive allosteric modulators of the GABA(B) receptor to reduce alcohol self-administration in rats. To this end, selectively bred Sardinian alcohol-preferring (sP) rats were initially trained to respond on a lever [on a fixed ratio 4 (FR4) schedule of reinforcement] to orally self-administer alcohol (15%, v/v) or sucrose (0.7%, w/v) in daily 30-min sessions. Once responding reached stable levels, the effect of rac-BHFF (0, 50, 100, and 200mg/kg; i.g.) on responding for alcohol and sucrose was determined. Pretreatment with rac-BHFF produced a dose-dependent suppression in responding for alcohol; reduction in the total number of responses for alcohol, in comparison to vehicle-treated rats, averaged approximately 30%, 65%, and 90% in 50, 100, and 200mg/kg rac-BHFF-treated rats, respectively. Pretreatment with 200mg/kg rac-BHFF markedly increased the latency to the first response on the alcohol lever. The effect of pretreatment with rac-BHFF on alcohol self-administration was highly specific, since (a) responding for sucrose was reduced (to approximately 50%, in comparison to vehicle-treated rats) only by pretreatment with 200mg/kg rac-BHFF, and (b) latency to the first response on the sucrose lever was completely unaltered by any rac-BHFF dose. Treatment with rac-BHFF did not alter spontaneous locomotor activity in an independent group of sP rats. The present data constitute a further piece of evidence on the capacity of positive allosteric modulators of the GABA(B) receptor to reduce alcohol's reinforcing properties in rats. . (literal)

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