Treatment of human cancer cells with selenite or tellurite in combination with auranofin enhances (Articolo in rivista)

Type
Label
  • Treatment of human cancer cells with selenite or tellurite in combination with auranofin enhances (Articolo in rivista) (literal)
Anno
  • 2009-01-01T00:00:00+01:00 (literal)
Http://www.cnr.it/ontology/cnr/pubblicazioni.owl#doi
  • 10.1016/j.freeradbiomed.2009.05.027 (literal)
Alternative label
  • Rigobello M.P., Gandin V., Folda A., Rundlöf A.K., Fernandes AP., Bindoli A., Marzano C., (2009)
    Treatment of human cancer cells with selenite or tellurite in combination with auranofin enhances
    in Free radical biology & medicine
    (literal)
Http://www.cnr.it/ontology/cnr/pubblicazioni.owl#autori
  • Rigobello M.P., Gandin V., Folda A., Rundlöf A.K., Fernandes AP., Bindoli A., Marzano C., (literal)
Pagina inizio
  • 710 (literal)
Pagina fine
  • 721 (literal)
Http://www.cnr.it/ontology/cnr/pubblicazioni.owl#numeroVolume
  • 47 (literal)
Rivista
Note
  • ISI Web of Science (WOS) (literal)
Http://www.cnr.it/ontology/cnr/pubblicazioni.owl#affiliazioni
  • Dipartimento di Chimica Biologica, Università di Padova, 35121 Padova, Italy Dipartimento di Scienze Farmaceutiche, Università di Padova, 35121 Padova, Italy Division of Pathology F46, Department of Laboratory Medicine, Karolinska Institutet, Karolinska University Hospital Huddinge, SE-141 86 Stockholm, Sweden Istituto di Neuroscienze (CNR), Viale G. Colombo 3, 35121 Padova, Italy (literal)
Titolo
  • Treatment of human cancer cells with selenite or tellurite in combination with auranofin enhances (literal)
Abstract
  • Selenium is an essential trace element incorporated as selenocysteine in 25 human selenoproteins. Among them are thioredoxin reductases (TrxR) and glutathione peroxidases, all central proteins in the regulation of the cellular thiol redox state. In this paper the effects of selenite and tellurite treatment in human cancer cells are reported and compared. Our results show that both selenite and tellurite, at relatively low concentrations, are able to increase the expression of mitochondrial and cytosolic TrxR in cisplatin-sensitive (2008) and -resistant (C13?) phenotypes. We further investigated the cellular effects induced by selenite or tellurite in combination with the specific TrxR inhibitor auranofin. Selenite pretreatment induced a dramatic increase in auranofin cytotoxicity in both resistant and sensitive cells. Investigation of TrxR activity and expression levels as well as the cellular redox state demonstrated the involvement of TrxR inhibition and redox changes in selenite and auranofin combined action. (literal)
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