http://www.cnr.it/ontology/cnr/individuo/prodotto/ID38600

Changes in expression and function of extrasynaptic GABAA receptors in the rat hippocampus during pregnancy and after delivery (Articolo in rivista)

Type

Articolo in rivista (Classe)
Prodotto della ricerca (Classe)

Label

Changes in expression and function of extrasynaptic GABAA receptors in the rat hippocampus during pregnancy and after delivery (Articolo in rivista) (literal)

Anno

2009-01-01T00:00:00+01:00 (literal)

Http://www.cnr.it/ontology/cnr/pubblicazioni.owl#doi

10.1523/JNEUROSCI.3684-08.2009 (literal)

Alternative label

Sanna E.; Mostallino M.C.; Murru L.; Carta M.; Talani G.; Zucca S.; Mura M.L.; Maciocco E.; Biggio G (2009)
Changes in expression and function of extrasynaptic GABAA receptors in the rat hippocampus during pregnancy and after delivery
in The Journal of neuroscience
(literal)

Http://www.cnr.it/ontology/cnr/pubblicazioni.owl#autori

Sanna E.; Mostallino M.C.; Murru L.; Carta M.; Talani G.; Zucca S.; Mura M.L.; Maciocco E.; Biggio G (literal)

Pagina inizio

1755 (literal)

Pagina fine

1765 (literal)

Http://www.cnr.it/ontology/cnr/pubblicazioni.owl#url

http://www.jneurosci.org (literal)

Http://www.cnr.it/ontology/cnr/pubblicazioni.owl#numeroVolume

26 (literal)

Rivista

?The ?Journal of neuroscience (Rivista)

Http://www.cnr.it/ontology/cnr/pubblicazioni.owl#pagineTotali

11 (literal)

Http://www.cnr.it/ontology/cnr/pubblicazioni.owl#numeroFascicolo

6 (literal)

Note

PubMe (literal)

Http://www.cnr.it/ontology/cnr/pubblicazioni.owl#affiliazioni

1Department of Experimental Biology, Section of Neuroscience, and 2Center of Excellence for the \"Neurobiology of Dependence,\" University of Cagliari, and 3National Research Council, Institute of Neuroscience, 09123 Cagliari, Italy (literal)

Titolo

Changes in expression and function of extrasynaptic GABAA receptors in the rat hippocampus during pregnancy and after delivery (literal)

Abstract

Pregnancy is associated with changes in mood and anxiety level as well as with marked hormonal fluctuations. Increases in the brain concentrations of neuroactive steroids during pregnancy in rats are accompanied by changes in expression of subunits of the GABA type A receptor (GABA(A)-R) in the brain. Granule cells of the dentate gyrus (DGGCs) exhibit two components of inhibitory GABAergic transmission: a phasic component mediated by synaptic GABA(A)-Rs, and a tonic component mediated by extrasynaptic GABA(A)-Rs. Recordings of GABAergic currents were obtained from hippocampal slices prepared from rats in estrus, at pregnancy day 15 (P15) or P19, or at 2 d after delivery. Exogenous GABA or 3alpha,5alpha-THP induced an increase in tonic current in DGGCs that was significantly greater at P19 than in estrus. Neither tonic nor phasic currents were affected by pregnancy in CA1 pyramidal cells. Immunohistochemical analysis revealed a marked increase in the abundance of the delta subunit of the GABA(A)-R and a concomitant decrease in that of the gamma(2) subunit in the hippocampus at P19. Expression of the alpha(4) subunit did not change during pregnancy but was increased 2 d after delivery. Treatment of rats from P12 to P18 with the 5alpha-reductase inhibitor finasteride prevented the changes in tonic current and in delta and gamma(2) subunit expression normally apparent at P19. These data suggest that the number of extrasynaptic GABA(A)-Rs is increased in DGGCs during late pregnancy as a consequence of the associated marked fluctuations in the brain levels of neuroactive steroids. (literal)

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