Impaired neurogenesis, learning and memory and low seizure threshold associated with loss of neural precursor cell survivin (Articolo in rivista)

Type

• Articolo in rivista (Classe)
• Prodotto della ricerca (Classe)

Label

• Impaired neurogenesis, learning and memory and low seizure threshold associated with loss of neural precursor cell survivin (Articolo in rivista) (literal)

Anno

• 2010-01-01T00:00:00+01:00 (literal)

Http://www.cnr.it/ontology/cnr/pubblicazioni.owl#doi

• 10.1186/1471-2202-11-2 (literal)

Alternative label

• Coremans V, Ahmed T, Balschun D, D'Hooge R, DeVriese A, Cremer J, Antonucci F, Moons M, Cremer H, Eisch A, Lagance D, Janssens T, Bozzi Y, Caleo M, Conway E (2010)
  Impaired neurogenesis, learning and memory and low seizure threshold associated with loss of neural precursor cell survivin
  in BMC neuroscience (Online)
  (literal)

Http://www.cnr.it/ontology/cnr/pubblicazioni.owl#autori

• Coremans V, Ahmed T, Balschun D, D'Hooge R, DeVriese A, Cremer J, Antonucci F, Moons M, Cremer H, Eisch A, Lagance D, Janssens T, Bozzi Y, Caleo M, Conway E (literal)

Pagina inizio

• 11 (literal)

Pagina fine

• 20 (literal)

Rivista

• BMC neuroscience (Rivista)

Note

• ISI Web of Science (WOS) (literal)

Http://www.cnr.it/ontology/cnr/pubblicazioni.owl#affiliazioni

• Istituto Neuroscienze CNR Pisa (literal)

Titolo

• Impaired neurogenesis, learning and memory and low seizure threshold associated with loss of neural precursor cell survivin (literal)

Abstract

• Background: Survivin is a unique member of the inhibitor of apoptosis protein (IAP) family in that it exhibits antiapoptotic properties and also promotes the cell cycle and mediates mitosis as a chromosome passenger protein. Survivin is highly expressed in neural precursor cells in the brain, yet its function there has not been elucidated. Results: To examine the role of neural precursor cell survivin, we first showed that survivin is normally expressed in periventricular neurogenic regions in the embryo, becoming restricted postnatally to proliferating and migrating NPCs in the key neurogenic sites, the subventricular zone (SVZ) and the subgranular zone (SGZ). We then used a conditional gene inactivation strategy to delete the survivin gene prenatally in those neurogenic regions. Lack of embryonic NPC survivin results in viable, fertile mice (SurvivinCamcre) with reduced numbers of SVZ NPCs, absent rostral migratory stream, and olfactory bulb hypoplasia. The phenotype can be partially rescued, as intracerebroventricular gene delivery of survivin during embryonic development increases olfactory bulb neurogenesis, detected postnatally. SurvivinCamcre brains have fewer cortical inhibitory interneurons, contributing to enhanced sensitivity to seizures, and profound deficits in memory and learning. Conclusions: The findings highlight the critical role that survivin plays during neural development, deficiencies of which dramatically impact on postnatal neural function. (literal)

Prodotto di

• Patologie e invecchiamento del Sistema Nervoso Centrale (ME.P02.006.002) (Modulo)
• Istituto di neuroscienze (IN) (Istituto)

Autore CNR

• YURI BOZZI (Persona)
• MATTEO CALEO (Unità di personale interno)

Incoming links:

Autore CNR di

• MATTEO CALEO (Unità di personale interno)
• YURI BOZZI (Persona)

Prodotto

• Istituto di neuroscienze (IN) (Istituto)
• Patologie e invecchiamento del Sistema Nervoso Centrale (ME.P02.006.002) (Modulo)

Http://www.cnr.it/ontology/cnr/pubblicazioni.owl#rivistaDi

• BMC neuroscience (Rivista)