The postsynaptic density proteins Homer and Shank form a polymeric network structure. (Articolo in rivista)

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  • The postsynaptic density proteins Homer and Shank form a polymeric network structure. (Articolo in rivista) (literal)
Anno
  • 2009-01-01T00:00:00+01:00 (literal)
Http://www.cnr.it/ontology/cnr/pubblicazioni.owl#doi
  • 10.1016/j.cell.2009.01.050 (literal)
Alternative label
  • Hayashi MK, Tang C, Verpelli C, Narayanan R, Stearns MH, Xu RM, Li H, Sala C, and Hayashi Y (2009)
    The postsynaptic density proteins Homer and Shank form a polymeric network structure.
    in Cell (Cambridge)
    (literal)
Http://www.cnr.it/ontology/cnr/pubblicazioni.owl#autori
  • Hayashi MK, Tang C, Verpelli C, Narayanan R, Stearns MH, Xu RM, Li H, Sala C, and Hayashi Y (literal)
Pagina inizio
  • 159 (literal)
Pagina fine
  • 171 (literal)
Http://www.cnr.it/ontology/cnr/pubblicazioni.owl#numeroVolume
  • 137 (literal)
Rivista
Note
  • ISI Web of Science (WOS) (literal)
Http://www.cnr.it/ontology/cnr/pubblicazioni.owl#affiliazioni
  • 1RIKEN-MIT Neuroscience Research Center, The Picower Institute for Learning and Memory, Department of Brain and Cognitive Sciences, Massachusetts Institute of Technology, Cambridge, MA 02139, USA 2Brain Science Institute, RIKEN, Wako, Saitama 351-0198, Japan 3Biology Department, Brookhaven National Laboratory, Upton, NY 11973, USA 4Consiglio Nazionale delle Ricerche, Institute of Neuroscience and Department of Pharmacology, University of Milan, 20129 Milan, Italy 5Structural Biology Program, The Helen L. and Martin S. Kimmel Center for Biology and Medicine at the Skirball Institute of Biomolecular Medicine and Department of Pharmacology, New York University School of Medicine, New York, NY 10016, USA 6Present address: Graduate Program in Neuroscience, Department of Biology, Brandeis University, Waltham, MA 02453, USA 7Present address: Institute of Biophysics, Chinese Academy of Sciences, 15 Da Tun Road, Beijing 100101, China (literal)
Titolo
  • The postsynaptic density proteins Homer and Shank form a polymeric network structure. (literal)
Abstract
  • The postsynaptic density (PSD) is crucial for synaptic functions, but the molecular architecture retaining its structure and components remains elusive. Homer and Shank are among the most abundant scaffolding proteins in the PSD, working synergistically for maturation of dendritic spines. Here, we demonstrate that Homer and Shank, together, form a mesh-like matrix structure. Crystallographic analysis of this region revealed a pair of parallel dimeric coiled coils intercalated in a tail-to-tail fashion to form a tetramer, giving rise to the unique configuration of a pair of N-terminal EVH1 domains at each end of the coiled coil. In neurons, the tetramerization is required for structural integrity of the dendritic spines and recruitment of proteins to synapses. We propose that the Homer-Shank complex serves as a structural framework and as an assembly platform for other PSD proteins. (literal)
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