The GluR2 subunit inhibits tumor proliferation by inactivating the src-erk1/2 cascade and induces apoptosis by means of caspase 376-dependent activation in glioma cells. (Articolo in rivista)

Type

• Articolo in rivista (Classe)
• Prodotto della ricerca (Classe)

Label

• The GluR2 subunit inhibits tumor proliferation by inactivating the src-erk1/2 cascade and induces apoptosis by means of caspase 376-dependent activation in glioma cells. (Articolo in rivista) (literal)

Anno

• 2009-01-01T00:00:00+01:00 (literal)

Http://www.cnr.it/ontology/cnr/pubblicazioni.owl#doi

• 10.1111/j.1460-9568.2009.06804.x (literal)

Alternative label

• Beretta F, Bassani S, Binda E, Verpelli C, Bello L, Galli R, Passafaro M (2009)
  The GluR2 subunit inhibits tumor proliferation by inactivating the src-erk1/2 cascade and induces apoptosis by means of caspase 376-dependent activation in glioma cells.
  in European journal of neuroscience (Print)
  (literal)

Http://www.cnr.it/ontology/cnr/pubblicazioni.owl#autori

• Beretta F, Bassani S, Binda E, Verpelli C, Bello L, Galli R, Passafaro M (literal)

Pagina inizio

• 25 (literal)

Pagina fine

• 34 (literal)

Http://www.cnr.it/ontology/cnr/pubblicazioni.owl#numeroVolume

• 30 (literal)

Rivista

• European journal of neuroscience (Rivista)

Note

• ISI Web of Science (WOS) (literal)

Http://www.cnr.it/ontology/cnr/pubblicazioni.owl#affiliazioni

• 1)DTI Dulbecco Telethon Institute, Via Vanvitelli 32, Milan 20129, Italy 2)Department of Pharmacology, CNR Institute of Neuroscience, Cellular and Molecular Pharmacology, University of Milan, Italy 3)CNR Institute of Neuroscience, Department of Pharmacology, University of Milan, Via Vanvitelli 32, Milan 20129, Italy 4)Unit of Neurosurgery, Fondazione Istituto di Ricovero e Cura a Carattere Scientifico Ospedale Maggiore Policlinico, University of Milan, Milan, Italy (literal)

Titolo

• The GluR2 subunit inhibits tumor proliferation by inactivating the src-erk1/2 cascade and induces apoptosis by means of caspase 376-dependent activation in glioma cells. (literal)

Abstract

• Glioblastoma multiforme (GBM) is the most invasive and undifferentiated type of brain tumour, and so surgical interventions are ineffective. We found that GluR2 is absent in fast-growing GBM-derived tumour stem cells and high-grade glioma specimens, but is expressed in slow-growing stem cells and low-grade glioma specimens. More remarkably, GluR2 overexpression in U-87MG cells inhibits proliferation by inactivating extracellular signal-regulated kinase (ERK)1 ? 2-Src phosphorylation and induces apoptosis. Mechanistically, we observed that the scaffold protein GRIP is essential for the effect of GluR2 on ERK-Src inactivation. These findings indicate that the absence of the GluR2 subunit favours malignancy. (literal)

Prodotto di

• Istituto di neuroscienze (IN) (Istituto)
• Farmacologia Cellulare e Molecolare delle Cellule Nervose (ME.P02.007.001) (Modulo)

Autore CNR

• SILVIA BASSANI (Unità di personale esterno)
• MARIA PASSAFARO (Unità di personale interno)

Insieme di parole chiave

• Keywords of "The GluR2 subunit inhibits tumor proliferation by inactivating the src-erk1/2 cascade and induces apoptosis by means of caspase 376-dependent activation in glioma cells." (Insieme di parole chiave)

Incoming links:

Autore CNR di

• MARIA PASSAFARO (Unità di personale interno)
• SILVIA BASSANI (Unità di personale esterno)

Prodotto

• Istituto di neuroscienze (IN) (Istituto)
• Farmacologia Cellulare e Molecolare delle Cellule Nervose (ME.P02.007.001) (Modulo)

Http://www.cnr.it/ontology/cnr/pubblicazioni.owl#rivistaDi

• European journal of neuroscience (Rivista)

Insieme di parole chiave di

• Keywords of "The GluR2 subunit inhibits tumor proliferation by inactivating the src-erk1/2 cascade and induces apoptosis by means of caspase 376-dependent activation in glioma cells." (Insieme di parole chiave)