The VGF-derived peptide TLQP-21: a new modulatory peptide for inflammatory pain (Articolo in rivista)

Type

• Prodotto della ricerca (Classe)
• Articolo in rivista (Classe)

Label

• The VGF-derived peptide TLQP-21: a new modulatory peptide for inflammatory pain (Articolo in rivista) (literal)

Anno

• 2008-01-01T00:00:00+01:00 (literal)

Alternative label

• Rizzi R., Bartolomucci A., Moles A., D'Amato F, Sacerdote P., Levi A., La Corte G., Ciotti M.G, Possenti R., Pavone F (2008)
  The VGF-derived peptide TLQP-21: a new modulatory peptide for inflammatory pain
  in Neuroscience letters (Print)
  (literal)

Http://www.cnr.it/ontology/cnr/pubblicazioni.owl#autori

• Rizzi R., Bartolomucci A., Moles A., D'Amato F, Sacerdote P., Levi A., La Corte G., Ciotti M.G, Possenti R., Pavone F (literal)

Pagina inizio

• 129 (literal)

Pagina fine

• 133 (literal)

Http://www.cnr.it/ontology/cnr/pubblicazioni.owl#numeroVolume

• 441 (literal)

Rivista

• Neuroscience letters (Rivista)

Note

• ISI Web of Science (WOS) (literal)

Http://www.cnr.it/ontology/cnr/pubblicazioni.owl#affiliazioni

• CNR, Institute of Neuroscience, Roma, Italy Department of Pharmacology, University of Milano, Milano, Italy CNR, Institute of Neurobiology and Molecular Medicine, Roma, Italy Department of Neuroscience, University of Tor Vergata, Roma, Italy (literal)

Titolo

• The VGF-derived peptide TLQP-21: a new modulatory peptide for inflammatory pain (literal)

Abstract

• Vgf, is a neuro-endocrine specific gene encoding for a large protein precursor of different peptides. A role for VGF in pain modulation has been suggested from immunohistochemical studies showing VGF mRNA widely expressed in primary sensory neurons. In this study, the presence of VGF on the primary sensory afferents in mice was confirmed by showing its immunostaining in cultured neurons of dorsal root ganglia in secretory granule varicosities colocalized with Substance P. Moreover, the functional role of a C-terminal internal VGF-derived peptide, i.e. TLQP-21, was assessed by investigating its peripheral (1, 2, 4, 8 mM) and central (1, 2, 4 mM) effects on inflammatory pain in the formalin test. A significant increase of pain-related licking response following peripheral injection of TLQP-21 (4 and 8 mM) was observed in the second inflammatory phase of the test. In addition, an increase in licking response was detected when 4 mM of the peptide was injected alone without formalin. On the other hand, the central administration of TLQP-21 induced an U-shaped curve, with the dose of 2 mM being analgesic during the second phase. This study shows for the first time that a VGF-derived peptide may be involved in inflammatory pain in vivo and demonstrates a different action for TLQP21 at the peripheral and central levels of the nociceptive pathways. (literal)

Prodotto di

• Modelli animali di deficit neurocomportamentale: meccanismi di adattamento a stress - modelli animali (SV.P16.003.001) (Modulo)
• Istituto di neuroscienze (IN) (Istituto)
• Modelli animali per lo studio del sistema nervoso (ME.P05.007.001) (Modulo)

Autore CNR

• FLAMINIA PAVONE (Unità di personale interno)
• FRANCESCA ROMANA D'AMATO (Persona)
• ANNA MOLES (Unità di personale interno)

Incoming links:

Autore CNR di

• ANNA MOLES (Unità di personale interno)
• FLAMINIA PAVONE (Unità di personale interno)
• FRANCESCA ROMANA D'AMATO (Persona)

Prodotto

• Istituto di neuroscienze (IN) (Istituto)
• Modelli animali di deficit neurocomportamentale: meccanismi di adattamento a stress - modelli animali (SV.P16.003.001) (Modulo)
• Modelli animali per lo studio del sistema nervoso (ME.P05.007.001) (Modulo)

Http://www.cnr.it/ontology/cnr/pubblicazioni.owl#rivistaDi

• Neuroscience letters (Rivista)