http://www.cnr.it/ontology/cnr/individuo/prodotto/ID38530
The promnesic effect of G-protein-coupled 5-HT4 receptors activation is mediated by a potentiation of learning-induced spine growth in the mouse hippocampus (Articolo in rivista)
- Type
- Label
- The promnesic effect of G-protein-coupled 5-HT4 receptors activation is mediated by a potentiation of learning-induced spine growth in the mouse hippocampus (Articolo in rivista) (literal)
- Anno
- 2008-01-01T00:00:00+01:00 (literal)
- Http://www.cnr.it/ontology/cnr/pubblicazioni.owl#doi
- 10.1038/sj.npp.1301644 (literal)
- Alternative label
Restivo L, Roman F, Dumuis A, Bockaert J, Marchetti E, Ammassari-Teule M (2008)
The promnesic effect of G-protein-coupled 5-HT4 receptors activation is mediated by a potentiation of learning-induced spine growth in the mouse hippocampus
in Neuropsychopharmacology (N.Y. N.Y.)
(literal)
- Http://www.cnr.it/ontology/cnr/pubblicazioni.owl#autori
- Restivo L, Roman F, Dumuis A, Bockaert J, Marchetti E, Ammassari-Teule M (literal)
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- Http://www.cnr.it/ontology/cnr/pubblicazioni.owl#url
- http://www.nature.com/npp/journal/v33/n10/full/1301644a.html (literal)
- Http://www.cnr.it/ontology/cnr/pubblicazioni.owl#numeroVolume
- Rivista
- Note
- ISI Web of Science (WOS) (literal)
- Http://www.cnr.it/ontology/cnr/pubblicazioni.owl#affiliazioni
- Istituto di Neuroscienze (literal)
- Titolo
- The promnesic effect of G-protein-coupled 5-HT4 receptors activation is mediated by a potentiation of learning-induced spine growth in the mouse hippocampus (literal)
- Abstract
- Pharmacological modulation of synaptic efficacy is a prominent target in the identification of promnesic compounds. Here, we report that
pretraining administration of the serotonin 5-HT4 receptors (5-HT4Rs) partial agonist SL65.0155 enhances simultaneous olfactory
discrimination performance and potentiates learning-induced dendritic spine growth in the mouse hippocampus. SL65.0155 does not
affect spine density in the pseudo-trained mice and, by itself, does not promote spine growth. Injecting the 5-HT4 antagonist RS39604
prior to SL65.0155 prevents both the increase in performance and the additional formation of spines, thus confirming the 5-HT4Rs
specificity of the observed effects. These findings provide evidence that 5-HT4Rs stimulation selectively increases experience-dependent
structural plasticity in learning-activated hippocampal circuits. (literal)
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