Interaction with stressed mothers affects corticosterone levels in pups after reunion and impairs the response to dexamethasone in adult mice (Articolo in rivista)

Type

• Articolo in rivista (Classe)
• Prodotto della ricerca (Classe)

Label

• Interaction with stressed mothers affects corticosterone levels in pups after reunion and impairs the response to dexamethasone in adult mice (Articolo in rivista) (literal)

Anno

• 2008-01-01T00:00:00+01:00 (literal)

Alternative label

• Moles A; Sarli C; Bartolomucci A; D'Amato FR. (2008)
  Interaction with stressed mothers affects corticosterone levels in pups after reunion and impairs the response to dexamethasone in adult mice
  in Psychoneuroendocrinology
  (literal)

Http://www.cnr.it/ontology/cnr/pubblicazioni.owl#autori

• Moles A; Sarli C; Bartolomucci A; D'Amato FR. (literal)

Pagina inizio

• 462 (literal)

Pagina fine

• 470 (literal)

Http://www.cnr.it/ontology/cnr/pubblicazioni.owl#numeroVolume

• 33 (literal)

Rivista

• Psychoneuroendocrinology (Rivista)

Note

• ISI Web of Science (WOS) (literal)

Http://www.cnr.it/ontology/cnr/pubblicazioni.owl#affiliazioni

• Institute of Neuroscience, CNR, Via del Fosso di Fiorano 64, 00137 Roma, Italy (literal)

Titolo

• Interaction with stressed mothers affects corticosterone levels in pups after reunion and impairs the response to dexamethasone in adult mice (literal)

Abstract

• Background: Early adverse experiences are preeminent factors for the development of affective disorders. In the present study, we analyzed the effects of different postnatal manipulations applied either on the mother or on the offspring in mice. Maternal behavior and adrenocortical activity of both mothers and offspring at the end of postnatal stress and at adulthood were considered. Methods: From postnatal day (PND) 1 to 14 mice underwent 15 min of: (a) brief (15 min) pups' exposure to clean bedding (CB: clean bedding), (b) mothers' exposure to the odor of a novel male (SM: stressed mother) or (c) mothers' exposure to a clean cage (CSM: control stressed mother), and (d) standard rearing (N-H: non-handled). The behavior of mouse dams during and after stress sessions was analyzed. Serum corticosterone of mothers and pups at the end of the stress session and 30 min after reunion was assessed on PND 14. Moreover, anxiety levels and HPA-axis inhibitory feedback in response to dexamethasone administration were evaluated in adult male offspring. Results: Overall, during the 14 days of treatment CB mothers when reunited with their pups showed higher maternal behavior than other dams. After the last stress (PND 14) SM and CSM maternal corticosterone levels increased as well as those of CB pups. While 30 min of mother-infant interaction restored baseline corticosterone levels in SM and CSM mothers and in CB pups, SM and CSM offspring showed a decrease of corticosterone under baseline levels. At adulthood, SM and CSM males did not show the suppressive hormonal response to dexamethasone treatment. Moreover, adult CB and SM male mice displayed decreased anxiety in the open field. (literal)

Prodotto di

• Istituto di neuroscienze (IN) (Istituto)
• Modelli animali per lo studio del sistema nervoso (ME.P05.007.001) (Modulo)
• Modelli animali di deficit neurocomportamentale: meccanismi di adattamento a stress - modelli animali (SV.P16.003.001) (Modulo)

Autore CNR

• FRANCESCA ROMANA D'AMATO (Persona)
• ANNA MOLES (Unità di personale interno)

Insieme di parole chiave

• Parole chiave di "Interaction with stressed mothers affects corticosterone levels in pups after reunion and impairs the response to dexamethasone in adult mice" (Insieme di parole chiave)

Incoming links:

Autore CNR di

• ANNA MOLES (Unità di personale interno)
• FRANCESCA ROMANA D'AMATO (Persona)

Prodotto

• Istituto di neuroscienze (IN) (Istituto)
• Modelli animali di deficit neurocomportamentale: meccanismi di adattamento a stress - modelli animali (SV.P16.003.001) (Modulo)
• Modelli animali per lo studio del sistema nervoso (ME.P05.007.001) (Modulo)

Http://www.cnr.it/ontology/cnr/pubblicazioni.owl#rivistaDi

• Psychoneuroendocrinology (Rivista)

Insieme di parole chiave di

• Parole chiave di "Interaction with stressed mothers affects corticosterone levels in pups after reunion and impairs the response to dexamethasone in adult mice" (Insieme di parole chiave)