http://www.cnr.it/ontology/cnr/individuo/prodotto/ID38475
A reappraisal of the central effects of botulinum neurotoxin type A: by what mechanism? (Articolo in rivista)
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- Label
- A reappraisal of the central effects of botulinum neurotoxin type A: by what mechanism? (Articolo in rivista) (literal)
- Anno
- 2009-01-01T00:00:00+01:00 (literal)
- Alternative label
Caleo M, Antonucci F, Restani L, Mazzocchio R. (2009)
A reappraisal of the central effects of botulinum neurotoxin type A: by what mechanism?
in Journal of neurochemistry
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- Caleo M, Antonucci F, Restani L, Mazzocchio R. (literal)
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- Matteo Caleo, CNR - Istituto di Neuroscienze, Pisa (literal)
- Titolo
- A reappraisal of the central effects of botulinum neurotoxin type A: by what mechanism? (literal)
- Abstract
- Botulinum neurotoxin A (BoNT/A) is a metalloprotease that enters peripheral motor nerve terminals and blocks the release of acetylcholine via the specific cleavage of the synaptosomal-associated protein of 25-kDa. Localized injections of BoNT/A are widely employed in clinical neurology to treat several human diseases characterized by muscle hyperactivity. It is generally assumed that the effects of BoNT/A remain localized to the injection site. However, several neurophysiological studies have provided evidence for central effects of BoNT/A, raising the issue of how these actions arise. Here we review these data and discuss the possibility that retrograde axonal transport of catalytically active BoNT/A may explain at least some of its effects at the level of central circuits. (literal)
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