A reappraisal of the central effects of botulinum neurotoxin type A: by what mechanism? (Articolo in rivista)

Type
Label
  • A reappraisal of the central effects of botulinum neurotoxin type A: by what mechanism? (Articolo in rivista) (literal)
Anno
  • 2009-01-01T00:00:00+01:00 (literal)
Alternative label
  • Caleo M, Antonucci F, Restani L, Mazzocchio R. (2009)
    A reappraisal of the central effects of botulinum neurotoxin type A: by what mechanism?
    in Journal of neurochemistry
    (literal)
Http://www.cnr.it/ontology/cnr/pubblicazioni.owl#autori
  • Caleo M, Antonucci F, Restani L, Mazzocchio R. (literal)
Pagina inizio
  • 15 (literal)
Pagina fine
  • 24 (literal)
Http://www.cnr.it/ontology/cnr/pubblicazioni.owl#numeroVolume
  • 109 (literal)
Rivista
Note
  • PubMe (literal)
Http://www.cnr.it/ontology/cnr/pubblicazioni.owl#affiliazioni
  • Matteo Caleo, CNR - Istituto di Neuroscienze, Pisa (literal)
Titolo
  • A reappraisal of the central effects of botulinum neurotoxin type A: by what mechanism? (literal)
Abstract
  • Botulinum neurotoxin A (BoNT/A) is a metalloprotease that enters peripheral motor nerve terminals and blocks the release of acetylcholine via the specific cleavage of the synaptosomal-associated protein of 25-kDa. Localized injections of BoNT/A are widely employed in clinical neurology to treat several human diseases characterized by muscle hyperactivity. It is generally assumed that the effects of BoNT/A remain localized to the injection site. However, several neurophysiological studies have provided evidence for central effects of BoNT/A, raising the issue of how these actions arise. Here we review these data and discuss the possibility that retrograde axonal transport of catalytically active BoNT/A may explain at least some of its effects at the level of central circuits. (literal)
Prodotto di
Autore CNR

Incoming links:


Autore CNR di
Prodotto
Http://www.cnr.it/ontology/cnr/pubblicazioni.owl#rivistaDi
data.CNR.it