Emerging Protein Targets for Anticancer Metallodrugs: Inhibition of Thioredoxin Reductase and Cathepsin B by Antitumor Ruthenium (II)-Arene Compounds. (Articolo in rivista)

Type

• Prodotto della ricerca (Classe)
• Articolo in rivista (Classe)

Label

• Emerging Protein Targets for Anticancer Metallodrugs: Inhibition of Thioredoxin Reductase and Cathepsin B by Antitumor Ruthenium (II)-Arene Compounds. (Articolo in rivista) (literal)

Anno

• 2008-01-01T00:00:00+01:00 (literal)

Http://www.cnr.it/ontology/cnr/pubblicazioni.owl#doi

• 10.1021/jm8006678 (literal)

Alternative label

• Casini A, Gabbiani C, Sorrentino F, Rigobello M.P., Bindoli A, Geldbach TJ, Marrone A, Re N, Hartinger CG , Dyson PJ, Messori L. (2008)
  Emerging Protein Targets for Anticancer Metallodrugs: Inhibition of Thioredoxin Reductase and Cathepsin B by Antitumor Ruthenium (II)-Arene Compounds.
  in Journal of medicinal chemistry
  (literal)

Http://www.cnr.it/ontology/cnr/pubblicazioni.owl#autori

• Casini A, Gabbiani C, Sorrentino F, Rigobello M.P., Bindoli A, Geldbach TJ, Marrone A, Re N, Hartinger CG , Dyson PJ, Messori L. (literal)

Pagina inizio

• 6773 (literal)

Pagina fine

• 6781 (literal)

Http://www.cnr.it/ontology/cnr/pubblicazioni.owl#numeroVolume

• 51 (literal)

Rivista

• Journal of medicinal chemistry (Rivista)

Note

• ISI Web of Science (WOS) (literal)

Http://www.cnr.it/ontology/cnr/pubblicazioni.owl#affiliazioni

• Department of Chemistry, UniVersity of Florence, Via della Lastruccia 3, 50019 Sesto Fiorentino, Firenze, Italy, Department of Biological Chemistry, UniVersity of PadoVa, Viale G. Colombo 3, 35121 PadoVa, Italy, Institute of Neurosciences (CNR), Section of PadoVa, Viale G. Colombo 3, 35121 PadoVa, Italy, Institut des Sciences et Inge´nierie Chimiques, Ecole Polytechnique Fe´de´rale de Lausanne (EPFL), CH-1015 Lausanne, Switzerland, and Dipartimento di Scienze del Farmaco, UniVersity G. d'Annunzio, Via dei Vestini 31, 66100 Chieti, Italy (literal)

Titolo

• Emerging Protein Targets for Anticancer Metallodrugs: Inhibition of Thioredoxin Reductase and Cathepsin B by Antitumor Ruthenium (II)-Arene Compounds. (literal)

Abstract

• A series of ruthenium(II)-arene (RAPTA) compounds were evaluated for their ability to inhibit thioredoxin reductase (either cytosolic or mitochondrial) and cathepsin B, two possible targets for anticancer metallodrugs. In general, inhibition of the thioredoxin reductases was lower than that of cathepsin B, although selected compounds were excellent inhibitors of both classes of enzymes in comparison to other metal-based drugs. Some initial structure-activity relationships could be established. On the basis of the obtained data, different mechanisms of binding/inhibition appear to be operative; remarkably the selectivity of the ruthenium compounds toward solid metastatic tumors also correlates to the observed trends. Notably, docking studies of the interactions of representative RAPTA compounds with cathepsin B were performed that provided realistic structures for the resulting protein-metallodrug adducts. Good agreement was generally found between the inhibiting potency of the RAPTA compounds and the computed stability of the corresponding cat B/RAPTA adducts. (literal)

Prodotto di

• Institute of neuroscience (IN) (Istituto)
• Neurobiologia e Neuropatologia (ME.P02.005.001) (Modulo)

Autore CNR

• ALBERTO BINDOLI (Unità di personale interno)

Incoming links:

Autore CNR di

• ALBERTO BINDOLI (Unità di personale interno)

Prodotto

• Institute of neuroscience (IN) (Istituto)
• Neurobiologia e Neuropatologia (ME.P02.005.001) (Modulo)

Http://www.cnr.it/ontology/cnr/pubblicazioni.owl#rivistaDi

• Journal of medicinal chemistry (Rivista)