Thiol chemistry in peroxidase catalysis and redox signaling. (Articolo in rivista)

Type
Label
  • Thiol chemistry in peroxidase catalysis and redox signaling. (Articolo in rivista) (literal)
Anno
  • 2008-01-01T00:00:00+01:00 (literal)
Http://www.cnr.it/ontology/cnr/pubblicazioni.owl#doi
  • 10.1089/ars.2008.2063 (literal)
Alternative label
  • Bindoli A.;Fukuto JM; Forman HJ (2008)
    Thiol chemistry in peroxidase catalysis and redox signaling.
    in Antioxidants & redox signalling
    (literal)
Http://www.cnr.it/ontology/cnr/pubblicazioni.owl#autori
  • Bindoli A.;Fukuto JM; Forman HJ (literal)
Pagina inizio
  • 1549 (literal)
Pagina fine
  • 1564 (literal)
Http://www.cnr.it/ontology/cnr/pubblicazioni.owl#numeroVolume
  • 10 (literal)
Rivista
Note
  • ISI Web of Science (WOS) (literal)
Http://www.cnr.it/ontology/cnr/pubblicazioni.owl#affiliazioni
  • Institute of Neurosciences (CNR) c/o Department of Biological Chemistry, University of Padova (Italy). Department of Pharmacology, University of California Los Angeles, Los Angeles, California. School of Natural Sciences, University of California Merced, Merced, California. (literal)
Titolo
  • Thiol chemistry in peroxidase catalysis and redox signaling. (literal)
Abstract
  • The oxidation chemistry of thiols and disulfides of biologic relevance is described. The review focuses on the interaction and kinetics of hydrogen peroxide with low-molecular-weight thiols and protein thiols and, in particular, on sulfenic acid groups, which are recognized as key intermediates in several thiol oxidation processes. In particular, sulfenic and selenenic acids are formed during the catalytic cycle of peroxiredoxins and glutathione peroxidases, respectively. In turn, these enzymes are in close redox communication with the thioredoxin and glutathione systems, which are the major controllers of the thiol redox state. Oxidants formed in the cell originate from several different sources, but the major producers are NADPH oxidases and mitochondria. However, a different role of the oxygen species produced by these sources is apparent as oxidants derived from NADPH oxidase are involved mainly in signaling processes, whereas those produced by mitochondria induce cell death in pathways including also the thioredoxin system, presently considered an important target for cancer chemotherapy. (literal)
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Autore CNR

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