http://www.cnr.it/ontology/cnr/individuo/prodotto/ID38394

Hyperactivity and novelty-induced hyperreactivity in mice lacking Rac3. (Articolo in rivista)

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Hyperactivity and novelty-induced hyperreactivity in mice lacking Rac3. (Articolo in rivista) (literal)

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Alternative label

Corbetta, S (Corbetta, Sara)1; D'Adarno, P (D'Adarno, Patrizia)2; Gualdoni, S (Gualdoni, Sara)1; Braschi, C (Braschi, Chiara)4; Berardi, N (Berardi, Nicoletta)4; de Curtis, I (de Curtis, Ivan)1 (2008)
Hyperactivity and novelty-induced hyperreactivity in mice lacking Rac3.
in Behavioural brain research; ELSEVIER SCIENCE BV, PO BOX 211, 1000 AE AMSTERDAM, NETHERLANDS, AMSTERDAM (Paesi Bassi)
(literal)

Http://www.cnr.it/ontology/cnr/pubblicazioni.owl#autori

Corbetta, S (Corbetta, Sara)1; D'Adarno, P (D'Adarno, Patrizia)2; Gualdoni, S (Gualdoni, Sara)1; Braschi, C (Braschi, Chiara)4; Berardi, N (Berardi, Nicoletta)4; de Curtis, I (de Curtis, Ivan)1 (literal)

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1. Ist Sci San Raffaele, Cell Adhes Unit, I-20132 Milan, Italy 2. Ist Sci San Raffaele, Dulbecco Telethon Inst, Mol Genet Mental Retardat Unit, I-20132 Milan, Italy 3. Univ Florence, Dept Psychol, I-56100 Pisa, Italy 4. CNR, Inst Neurosci, I-56100 Pisa, Italy (literal)

Titolo

Hyperactivity and novelty-induced hyperreactivity in mice lacking Rac3. (literal)

Abstract

Rho family GTPases have been implicated as important regulators of neuronal development. Rac3 is a member of this family specifically expressed in vertebrate developing neurons, where it is coexpressed with the ubiquitous Rac1 GTPase. We have previously shown that Rac3 knockout mice are viable and fertile. The Rac3 protein shows highest expression around postnatal day 7 in brain regions relevant for cognitive behaviors. In this study we find that Rac3 knockout mice do not show defects in spatial reference memory assessed with water maze task, but they show a reduced behavioral flexibility to novel situations. Analysis of explorative behavior revealed hyperactive behavior and hyperreactivity to the presentation of new stimuli, as assessed by dark/light box, emergence and novel object tests. These defects were not due to reduced visual abilities, since visual acuity and contrast sensitivity were comparable in Rac3 knockout and wildlype littermates. Our data reinforce the notion that Rho family GTPases are important for normal cognitive development, and highlight specific functions of Rac3 that cannot be compensated by the coexpressed homologous Rac1. (literal)

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