http://www.cnr.it/ontology/cnr/individuo/prodotto/ID38349

Specific reduction of alcohols motivational properties by the positive allosteric modulator of the GABAB receptor, GS39783 Comparison with the effect of the GABAB receptor direct agonist, baclofen (Articolo in rivista)

Type

Prodotto della ricerca (Classe)
Articolo in rivista (Classe)

Label

Specific reduction of alcohols motivational properties by the positive allosteric modulator of the GABAB receptor, GS39783 Comparison with the effect of the GABAB receptor direct agonist, baclofen (Articolo in rivista) (literal)

Anno

2008-01-01T00:00:00+01:00 (literal)

Http://www.cnr.it/ontology/cnr/pubblicazioni.owl#doi

10.1111/j.1530-0277.2008.00725.x (literal)

Alternative label

Maccioni P., Fantini N., Froestl W., Carai M.A.M., Gessa G.L., Colombo G (2008)
Specific reduction of alcohols motivational properties by the positive allosteric modulator of the GABAB receptor, GS39783 Comparison with the effect of the GABAB receptor direct agonist, baclofen
in Alcoholism, clinical and experimental research; Wiley-Blackwell Publishing, Inc., Malden (Stati Uniti d'America)
(literal)

Http://www.cnr.it/ontology/cnr/pubblicazioni.owl#autori

Maccioni P., Fantini N., Froestl W., Carai M.A.M., Gessa G.L., Colombo G (literal)

Pagina inizio

1558 (literal)

Pagina fine

1564 (literal)

Http://www.cnr.it/ontology/cnr/pubblicazioni.owl#numeroVolume

32 (literal)

Rivista

Alcoholism, clinical and experimental research (Rivista)

Http://www.cnr.it/ontology/cnr/pubblicazioni.owl#pagineTotali

7 (literal)

Http://www.cnr.it/ontology/cnr/pubblicazioni.owl#numeroFascicolo

9 (literal)

Note

Google Scholar (literal)
PubMed (literal)
Scopus (literal)
ISI Web of Science (WOS) (literal)

Http://www.cnr.it/ontology/cnr/pubblicazioni.owl#affiliazioni

Neuroscience Institute, National Research Council of Italy, Section of Cagliari, Italy; Department of Neuroscience, University of Cagliari, Italy; AC Immune SA, Lausanne, Switzerland. (literal)

Titolo

Specific reduction of alcohols motivational properties by the positive allosteric modulator of the GABAB receptor, GS39783 Comparison with the effect of the GABAB receptor direct agonist, baclofen (literal)

Abstract

Activation of the GABA(B) receptor--either by means of direct agonists (like baclofen) or positive allosteric modulators (like GS39783)--has been observed to suppress alcohol drinking and reinforcement in rats and mice. The present study was conducted to assess and compare the effect of baclofen and GS39783 on the motivational properties of alcohol. METHODS: Selectively bred Sardinian alcohol-preferring (sP) rats were initially trained to respond on a lever (on an fixed ratio 4 schedule of reinforcement) to orally self-administer alcohol (15%, v/v) or sucrose (3%, w/v) in daily 30-minute sessions. Once lever-responding reached stable levels, rats were exposed to sessions with a progressive ratio schedule of reinforcement. The effect of nonsedative doses of baclofen (0, 1, and 3 mg/kg, i.p.) and GS39783 (0, 25, 50, and 100 mg/kg, i.g.) on breakpoint for alcohol and sucrose (defined as the lowest response requirement not achieved by each rat and used as index of the motivational strength of alcohol and sucrose) was determined. RESULTS: Baclofen administration resulted in a dose-dependent decrease in breakpoint for alcohol; this effect was not specific, as baclofen also reduced--to a comparable extent--breakpoint for sucrose. Conversely, GS39783 administration resulted in a dose-dependent and completely specific reduction in breakpoint for alcohol. CONCLUSIONS: The present results (i) confirm previous data on baclofen's capacity to suppress, although nonspecifically, alcohol's motivational properties, and (ii) extend to alcohol's motivational properties the capacity of GS39783 to inhibit alcohol drinking and reinforcement in rats. (literal)

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