Neuroactive steroids and GABA(A) receptor plasticity in the brain of the WAG/Rij rat, a model of absence epilepsy (Articolo in rivista)

Type

• Articolo in rivista (Classe)
• Prodotto della ricerca (Classe)

Label

• Neuroactive steroids and GABA(A) receptor plasticity in the brain of the WAG/Rij rat, a model of absence epilepsy (Articolo in rivista) (literal)

Anno

• 2008-01-01T00:00:00+01:00 (literal)

Http://www.cnr.it/ontology/cnr/pubblicazioni.owl#doi

• 10.1111/j.1471-4159.2008.05538.x (literal)

Alternative label

• Pisu M.G., Mostallino M.C., Dore R., Mura M.L., Maciocco E., Russo E., De Sarro G., Serra M. (2008)
  Neuroactive steroids and GABA(A) receptor plasticity in the brain of the WAG/Rij rat, a model of absence epilepsy
  in Journal of neurochemistry
  (literal)

Http://www.cnr.it/ontology/cnr/pubblicazioni.owl#autori

• Pisu M.G., Mostallino M.C., Dore R., Mura M.L., Maciocco E., Russo E., De Sarro G., Serra M. (literal)

Pagina inizio

• 2502 (literal)

Pagina fine

• 2514 (literal)

Http://www.cnr.it/ontology/cnr/pubblicazioni.owl#url

• http://onlinelibrary.wiley.com (literal)

Http://www.cnr.it/ontology/cnr/pubblicazioni.owl#numeroVolume

• 106 (literal)

Rivista

• Journal of neurochemistry (Rivista)

Http://www.cnr.it/ontology/cnr/pubblicazioni.owl#pagineTotali

• 13 (literal)

Http://www.cnr.it/ontology/cnr/pubblicazioni.owl#numeroFascicolo

• 6 (literal)

Note

• ISI Web of Science (WOS) (literal)

Http://www.cnr.it/ontology/cnr/pubblicazioni.owl#affiliazioni

• Department of Experimental Biology, University of Cagliari, Cagliari; Department of Experimental and Clinical Medicine, University \"Magna Grecia\" of Catanzaro, Catanzaro, Institute of Neuroscience, CNR, Cagliari (literal)

Titolo

• Neuroactive steroids and GABA(A) receptor plasticity in the brain of the WAG/Rij rat, a model of absence epilepsy (literal)

Abstract

• The role of neuroactive steroids and GABA(A) receptors in the generation of spontaneous spike-and-wave discharges (SWDs) was investigated in the WAG/Rij rat model of absence epilepsy. The plasma, cerebrocortical, and thalamic concentrations of the progesterone metabolite 3alpha-hydroxy-5alpha-pregnan-20-one (3alpha,5alpha-TH PROG) were increased in the WAG/Rij rat at 2 months of age compared with those in control (Wistar) rats. In contrast, the brain and peripheral levels of 3alpha,5alpha-tetrahydrodeoxycorticosterone (3alpha,5alpha-TH DOC) did not differ between the two rat strains at this age. At 6 months of age, when absence epilepsy worsens in WAG/Rij rats, the plasma concentration of 3alpha,5alpha-TH PROG remained high whereas that of 3alpha,5alpha-TH DOC had increased, the cerebrocortical levels of both 3alpha,5alpha-TH PROG and 3alpha,5alpha-TH DOC had increased, and the thalamic concentrations of these metabolites had decreased. At 6 months of age the expression of the alpha(4) and delta subunits of the GABA(A) receptor in relay nuclei was increased. Finally, chronic stress induced by social isolation elicited a reduction in the amount of 3alpha,5alpha-TH PROG in the thalamus of 2-month-old WAG/Rij rats that was associated with a reduction in the number and overall duration of SWDs at 6 months of age. Absence epilepsy in the WAG/Rij rat is thus associated with changes in the abundance of neuroactive steroids and in the expression of specific GABA(A) receptor subunits in the thalamus, a brain area key to the pathophysiology of this condition. (literal)

Prodotto di

• Istituto di neuroscienze (IN) (Istituto)
• Neurobiologia delle dipendenze (ME.P02.009.001) (Modulo)

Autore CNR

• ELISABETTA MACIOCCO (Unità di personale interno)
• MARIA CRISTINA MOSTALLINO (Persona)
• MARIA GIUSEPPINA PISU (Unità di personale interno)
• MARIA ANGELA SERRA (Unità di personale esterno)

Insieme di parole chiave

• Keywords of "Neuroactive steroids and GABA(A) receptor plasticity in the brain of the WAG/Rij rat, a model of absence epilepsy" (Insieme di parole chiave)

Incoming links:

Autore CNR di

• MARIA GIUSEPPINA PISU (Unità di personale interno)
• MARIA CRISTINA MOSTALLINO (Persona)
• ELISABETTA MACIOCCO (Unità di personale interno)
• MARIA ANGELA SERRA (Unità di personale esterno)

Prodotto

• Istituto di neuroscienze (IN) (Istituto)
• Neurobiologia delle dipendenze (ME.P02.009.001) (Modulo)

Http://www.cnr.it/ontology/cnr/pubblicazioni.owl#rivistaDi

• Journal of neurochemistry (Rivista)

Insieme di parole chiave di

• Keywords of "Neuroactive steroids and GABA(A) receptor plasticity in the brain of the WAG/Rij rat, a model of absence epilepsy" (Insieme di parole chiave)