Gold(III)-dithiocarbamato complexes induce cancer cell death triggered by (Articolo in rivista)

Type

• Articolo in rivista (Classe)
• Prodotto della ricerca (Classe)

Label

• Gold(III)-dithiocarbamato complexes induce cancer cell death triggered by (Articolo in rivista) (literal)

Anno

• 2007-01-01T00:00:00+01:00 (literal)

Http://www.cnr.it/ontology/cnr/pubblicazioni.owl#doi

• 10.1016/j.chembiol.2007.08.016 (literal)

Alternative label

• Saggioro D, Rigobello MP, Paloschi L, Folda A, Moggach SA, Parsons S, Ronconi L, (2007)
  Gold(III)-dithiocarbamato complexes induce cancer cell death triggered by
  in Chemistry & biology (Print)
  (literal)

Http://www.cnr.it/ontology/cnr/pubblicazioni.owl#autori

• Saggioro D, Rigobello MP, Paloschi L, Folda A, Moggach SA, Parsons S, Ronconi L, (literal)

Pagina inizio

• 1128 (literal)

Pagina fine

• 1139 (literal)

Http://www.cnr.it/ontology/cnr/pubblicazioni.owl#numeroVolume

• 14 (literal)

Rivista

• Chemistry & biology (Rivista)

Note

• ISI Web of Science (WOS) (literal)

Http://www.cnr.it/ontology/cnr/pubblicazioni.owl#affiliazioni

• Molecular Immunology and Diagnostic Oncology, Istituto Oncologico Veneto I.R.C.C.S., Via Gattamelata 64, Padova 35128, Italy Department of Biological Chemistry, University of Padova, V.le G. Colombo 3, Padova 35121, Italy Department of Oncology and Surgical Sciences, University of Padova, Via Gattamelata 64, Padova 35128, Italy School of Chemistry, University of Edinburgh, West Mains Road, Edinburgh EH9 3JJ, United Kingdom Department of Chemical Sciences, University of Padova, Via Marzolo 1, Padova 35131, Italy Institute of Neurosciences, C.N.R., V.le G. Colombo 3, Padova 35121, Italy (literal)

Titolo

• Gold(III)-dithiocarbamato complexes induce cancer cell death triggered by (literal)

Abstract

• Although gold compounds are now recognized as promising anticancer agents, so far only gold(I) derivatives have been investigated for this purpose, whereas the use of gold(III) complexes has been hampered by their poor stability under physiological conditions. We have therefore carried out studies on selected gold(III) anticancer agents, showing enhanced stability due to the presence of chelating dithiocarbamato ligands. We found that they induce cancer cell death through both apoptotic and nonapoptotic mechanisms. They also inhibit thioredoxin reductase activity, generate free radicals, modify some mitochondrial functions, and increase ERK1/2 phosphorylation. Based on our results, we propose and discuss a working model suggesting that deregulation of the thioredoxin reductase/thioredoxin redox system is a major mechanism involved in the anticancer activity of the investigated gold(III)-dithiocarbamato complexes (literal)

Prodotto di

• Institute of neuroscience (IN) (Istituto)
• Neurobiologia e Neuropatologia (ME.P02.005.001) (Modulo)

Autore CNR

• ALBERTO BINDOLI (Unità di personale interno)

Incoming links:

Autore CNR di

• ALBERTO BINDOLI (Unità di personale interno)

Prodotto

• Institute of neuroscience (IN) (Istituto)
• Neurobiologia e Neuropatologia (ME.P02.005.001) (Modulo)

Http://www.cnr.it/ontology/cnr/pubblicazioni.owl#rivistaDi

• Chemistry & biology (Rivista)