http://www.cnr.it/ontology/cnr/individuo/prodotto/ID38229
Activity of rat cytosolic thioredoxin reductase is strongly decreased by (Articolo in rivista)
- Type
- Label
- Activity of rat cytosolic thioredoxin reductase is strongly decreased by (Articolo in rivista) (literal)
- Anno
- 2007-01-01T00:00:00+01:00 (literal)
- Alternative label
Mura P, Camalli M, Bindoli A, Sorrentino F, Casini A, Gabbiani C, Corsini M, (2007)
Activity of rat cytosolic thioredoxin reductase is strongly decreased by
in Journal of medicinal chemistry
(literal)
- Http://www.cnr.it/ontology/cnr/pubblicazioni.owl#autori
- Mura P, Camalli M, Bindoli A, Sorrentino F, Casini A, Gabbiani C, Corsini M, (literal)
- Pagina inizio
- Pagina fine
- Http://www.cnr.it/ontology/cnr/pubblicazioni.owl#numeroVolume
- Rivista
- Note
- ISI Web of Science (WOS) (literal)
- Http://www.cnr.it/ontology/cnr/pubblicazioni.owl#affiliazioni
- Institute of Crystallography, Area della Ricerca di Roma 1 (CNR),
Via Salaria Km 29,300, Montelibretti, Rome, Italy, Istituto di
Neuroscienze (CNR), Sezione di PadoVa c/o Dipartimento di
Chimica Biologica, PadoVa, Italy, Dipartimento di Chimica
Biologica, UniVersita` degli Studi di PadoVa, Viale G. Colombo 3,
35121 PadoVa, Italy, Department of Chemistry, UniVersity of Siena,
Via De Gasperi 2, I-53100 Siena, Italy, and Department of
Chemistry, UniVersity of Florence, Via della Lastruccia 3,
50019 Sesto Fiorentino, Firenze, Italy (literal)
- Titolo
- Activity of rat cytosolic thioredoxin reductase is strongly decreased by (literal)
- Abstract
- A novel \"Keppler type\" ruthenium(III) compound trans-
[bis(2-amino 5-methylthiazole)tetrachlororuthenate(III)] 1, of potential
interest as an anticancer agent, was designed, synthesized, and
characterized. Its interactions with various proteins were analyzed,
including the selenoenzyme thioredoxin reductase, an emerging target
for anticancer metallodrugs. The selective inhibition of the cytosolic
form of this selenoenzyme was documented, this being the first report
of significant thioredoxin reductase inhibition by a ruthenium compound. (literal)
- Prodotto di
- Autore CNR
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