http://www.cnr.it/ontology/cnr/individuo/prodotto/ID38210

Reducing effect of the positive allosteric modulator of the GABAB receptor, GS39783, on alcohol self-administration in alcohol-preferring rats (Articolo in rivista)

Type

Prodotto della ricerca (Classe)
Articolo in rivista (Classe)

Label

Reducing effect of the positive allosteric modulator of the GABAB receptor, GS39783, on alcohol self-administration in alcohol-preferring rats (Articolo in rivista) (literal)

Anno

2007-01-01T00:00:00+01:00 (literal)

Http://www.cnr.it/ontology/cnr/pubblicazioni.owl#doi

10.1007/s00213-007-0776-1 (literal)

Alternative label

Maccioni P.; Pes D.; Orrù A.; Froestl W.; Gessa G.L.; Carai M.A.M.; Colombo G. (2007)
Reducing effect of the positive allosteric modulator of the GABAB receptor, GS39783, on alcohol self-administration in alcohol-preferring rats
in Psychopharmacology (Berlin. Internet); Springer-Verlag, Berlin/Heidelberg (Germania)
(literal)

Http://www.cnr.it/ontology/cnr/pubblicazioni.owl#autori

Maccioni P.; Pes D.; Orrù A.; Froestl W.; Gessa G.L.; Carai M.A.M.; Colombo G. (literal)

Pagina inizio

171 (literal)

Pagina fine

178 (literal)

Http://www.cnr.it/ontology/cnr/pubblicazioni.owl#numeroVolume

193 (literal)

Rivista

Psychopharmacology (Rivista)

Http://www.cnr.it/ontology/cnr/pubblicazioni.owl#pagineTotali

9 (literal)

Http://www.cnr.it/ontology/cnr/pubblicazioni.owl#numeroFascicolo

2 (literal)

Note

Google Scholar (literal)
PubMed (literal)
Scopus (literal)
ISI Web of Science (WOS) (literal)

Http://www.cnr.it/ontology/cnr/pubblicazioni.owl#affiliazioni

Neuroscience Institute, National Research Council of Italy, Section of Cagliari, Italy; Bernard B. Brodie\" Department of Neuroscience, University of Cagliari, Italy; AC Immune SA, Lausanne, Switzerland. (literal)

Titolo

Reducing effect of the positive allosteric modulator of the GABAB receptor, GS39783, on alcohol self-administration in alcohol-preferring rats (literal)

Abstract

Rationale and objectives: The positive allosteric modulator of the GABAB receptor, GS39783, has recently been found to suppress acquisition and maintenance of alcohol drinking behavior in selectively bred Sardinian alcohol-preferring (sP) rats exposed to the standard, homecage 2-bottle \"alcohol vs water\" choice regimen. The present study was designed to extend the characterization of the \"anti-alcohol\" effects of GS39783 to oral self-administration of alcohol under an operant procedure. Materials and methods: Two separate groups of male sP rats were trained to lever-press (on an FR4 schedule) to orally self-administer alcohol (15%, v/v) or sucrose (0.3%, w/v) in daily 30-min sessions. Once lever-pressing behavior reached stable levels, the effect of GS39783 (0, 25, 50, and 100 mg/kg, i.g.) on responding for alcohol and sucrose was determined. Results: Pretreatment with GS39783 resulted in a significant, dose-dependent reduction in responding for alcohol; at the dose of 100 mg/kg GS39783, the number of lever responses for alcohol was reduced by approximately 50% in comparison to vehicle-treated rats. The effect of GS39783 on alcohol self-administration was specific, since responding for sucrose was completely unaffected by pretreatment with GS39783. Conclusions: These data demonstrate the capability of GS39783 to attenuate the reinforcing properties of alcohol in alcohol-preferring rats. These data constitute a further piece of experimental evidence in support of the hypothesized role for the GABAB receptor in the control of alcohol drinking and reinforcement. (literal)

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