BoNT/E prevents seizure-induced activation of caspase 3 in the rat hippocampus. (Articolo in rivista)

Type

• Articolo in rivista (Classe)
• Prodotto della ricerca (Classe)

Label

• BoNT/E prevents seizure-induced activation of caspase 3 in the rat hippocampus. (Articolo in rivista) (literal)

Anno

• 2007-01-01T00:00:00+01:00 (literal)

Alternative label

• Manno I, Antonucci F, Caleo M, Bozzi Y. (2007)
  BoNT/E prevents seizure-induced activation of caspase 3 in the rat hippocampus.
  in NeuroReport (Oxf.)
  (literal)

Http://www.cnr.it/ontology/cnr/pubblicazioni.owl#autori

• Manno I, Antonucci F, Caleo M, Bozzi Y. (literal)

Pagina inizio

• 373 (literal)

Pagina fine

• 376 (literal)

Http://www.cnr.it/ontology/cnr/pubblicazioni.owl#numeroVolume

• 18 (literal)

Rivista

• NeuroReport (Rivista)

Note

• ISI Web of Science (WOS) (literal)

Http://www.cnr.it/ontology/cnr/pubblicazioni.owl#affiliazioni

• INCNR PISA (literal)

Titolo

• BoNT/E prevents seizure-induced activation of caspase 3 in the rat hippocampus. (literal)

Abstract

• Clinical and experimental studies clearly demonstrate that prolonged seizures and status epilepticus induce neuronal cell death in the brain. Recent evidence suggests that induction of apoptosis contributes greatly to seizure-induced brain damage. We recently demonstrated that intrahippocampal delivery of botulinum neurotoxin E (BoNT/E) in the rat hippocampus is able to prevent neuronal loss, which occurs after kainic-acid-induced seizures. Here, we investigated the molecular mechanisms of BoNT/E-mediated neuroprotection. We found that intrahippocampal administration of BoNT/E prevents the upregulation of apoptotic proteins (phosphorylated c-Jun and cleaved caspase 3), which occurs in hippocampal neurones following kainic acid seizures. These results demonstrate that the neuroprotective action of BoNT/E on seizure-injured hippocampal neurons involves the blockade of well-characterized apoptotic pathways. (literal)

Prodotto di

• Istituto di neuroscienze (IN) (Istituto)
• Neuropatologie: dall'approccio molecolare alla epidemiologia delle demenze (ME.P02.019.001) (Modulo)

Autore CNR

• YURI BOZZI (Persona)
• MATTEO CALEO (Unità di personale interno)
• FLAVIA ANTONUCCI (Unità di personale esterno)

Incoming links:

Autore CNR di

• MATTEO CALEO (Unità di personale interno)
• YURI BOZZI (Persona)
• FLAVIA ANTONUCCI (Unità di personale esterno)

Prodotto

• Istituto di neuroscienze (IN) (Istituto)
• Neuropatologie: dall'approccio molecolare alla epidemiologia delle demenze (ME.P02.019.001) (Modulo)

Http://www.cnr.it/ontology/cnr/pubblicazioni.owl#rivistaDi

• NeuroReport (Rivista)